A Study of Fluorescent Probe (VGT-309) in Identifying Cancerous Lesions During White-Light and NIR Augmented Colonoscopy in Patients with Colorectal Cancer

Inclusion Criteria

• Adult patients with histologically confirmed distal colorectal adenocarcinoma of any stage
• Be willing and able to sign the informed consent and comply with study procedures
• Are scheduled to undergo a SOC colonoscopy for restaging following radiochemotherapy or are scheduled to receive a SOC colonoscopy in the OR prior to resection
• Alanine aminotransferase (ALT) / aspartate aminotransferase (AST) ≤ 1.5 times the upper limit of normal
• Creatinine clearance (according to Cockcroft-Gault equation) > 50 mL/min
• Total bilirubin ≤ 1.5 times the upper limit of normal
• Have an Eastern Cooperative Oncology Group (ECOG) score of 0-2
• Be at least 18 years of age
• Female participants must be of non-childbearing potential, or, if of childbearing potential be non-pregnant or lactating and agree to use highly effective contraception from screening through 30 days after probe infusion
• Male participants, if not surgically sterilized, and if engaging in sexual intercourse with a female partner of childbearing potential, must be willing to use highly effective contraception from screening through 30 days post-dose and agree not to donate semen during this waiting period
• Highly effective contraception involves the use of a condom for the male, plus one of the following for the female: * Oral, injectable, implantable, intravaginal, or transdermal hormonal contraceptives, or * Intrauterine device or intrauterine hormone-releasing system
• NOTE: Participants who abstain from heterosexual intercourse as their usual and preferred lifestyle, will not be required to use contraception as described above. They are required to maintain abstinence from screening through day 30, AND participants in a same sex relationship, must use a barrier form of contraception (e.g., condom, diaphragm) to protect against the transfer of the study drug in any bodily fluids

Exclusion Criteria

• Pregnant or breastfeeding females
• They have a known allergy or reaction to indocyanine green (ICG), other radiographic contrast agents, or any component of VGT-309
• Have congenital long QT syndrome or QTcF > 450ms (males) or > 470ms (females) by history or at screening electrocardiogram (ECG)
• They are prisoners, institutionalized individuals, or are unable to consent for themselves
• Have any other comorbidity or habit that the Investigator believes will interfere with their ability to comply with and complete the study