Whole Breast Radiation Therapy with Simultaneous Integrated Boost for Patients with Early-stage, Invasive Breast Cancer or Ductal Carcinoma In Situ

This clinical trial studies how well whole breast radiation therapy with simultaneous integrated boost works for patients with early-stage breast cancer or ductal carcinoma in situ. Breast surgery along with radiation therapy is the standard of care for most patients and provides a reduction in cancer that comes back after a period of improvement (recurrence). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Standard treatment historically consisted of radiation therapy to the entire breast for 5 weeks followed by a “boost” treatment of radiation specifically targeting the tumor area for an additional 5-8 days. This trial uses a shortened whole breast radiation treatment along with the “boost” at the same time instead of following the treatment to ensure a shorter treatment timeframe while still delivering the same amount of radiation that would be utilized in the standard way. This trial is being done to find out what happens with patients after receiving the shortened treatment timeframe of whole breast radiation simultaneously with the “boost” treatment allowing for reduced treatment time from 10-12 days down to only 5 days.

Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06295744.

Trial PhaseNo phase specified

Trial Typetreatment

Lead OrganizationUniversity of Wisconsin Carbone Cancer Center - University Hospital

Principal InvestigatorJessica Moore Schuster

• Primary IDUW23114
• Secondary IDsNCI-2024-01891, 2023-1724
• ClinicalTrials.gov IDNCT06295744