Lisaftoclax, Olverembatinib, and Decitabine for the Treatment of Patients with Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

Inclusion Criteria

• Diagnosis: Age ≥ 18 years with CML-AP, CML-MBP, or Ph+ AML by World Health Organization (WHO) 2016 criteria * Patients must have been intolerant or resistant to at least one prior BCR::ABL1 tyrosine kinase inhibitor (TKI)
• Performance status ≤ 3 (Eastern Cooperative Oncology Group [ECOG] scale)
• Total serum bilirubin =< 1.5 x upper limit of normal (ULN), unless due to Gilbert’s syndrome, hemolysis or the underlying leukemia approved by the primary investigator (PI)
• Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 3 x ULN, unless due to the underlying leukemia approved by the PI
• Creatinine clearance ≥ 30 mL/min
• Serum amylase or lipase < 1.5 x ULN
• Ability to understand and the willingness to sign a written informed consent document
• Willingness to use adequate contraception prior to study entry, for the duration of study participation, and for 6 months after completion of study participation. For women of childbearing potential, adequate methods of contraception include: complete abstinence, hormonal contraception (i.e. birth control pills, injection, implant, transdermal patch, vaginal ring), intrauterine device (IUD), tubal Ligation or hysterectomy, subject/partner post vasectomy, implantable or injectable contraceptives, and condoms plus spermicide

Exclusion Criteria

• Patients who have previously received lisaftoclax or olverembatinib
• History of acute pancreatitis within 1 year of study or history of chronic pancreatitis
• Active grade III-V cardiac failure as defined by the New York Heart Association criteria
• Clinically significant and uncontrolled cardiovascular disease, including but not restricted to: * Myocardial infarction (MI), stroke, revascularization, unstable angina, or transient ischemic attack within 6 months. * Left ventricular ejection fraction (LVEF) less than lower limit of normal per local institutional standards prior to enrollment. * Diagnosed or suspected congenital long QT syndrome. * Clinically significant atrial or ventricular arrhythmias (such as uncontrolled, clinically significant atrial fibrillation, ventricular tachycardia, ventricular fibrillation, or Torsades de pointes) as determined by the treating physician. * Prolonged QTc interval on pre-entry electrocardiogram (> 480 msec) unless corrected after electrolyte replacement. * History of venous thromboembolism including deep venous thrombosis or pulmonary embolism within the past 3 months, excluding line associated deep vein thrombosis (DVT) of the upper extremity * Uncontrolled hypertension (diastolic blood pressure > 100mmHg and systolic > 150mmHg)
• Active serious infection not controlled by oral or intravenous antibiotics (e.g. persistent fever or lack of improvement despite antimicrobial treatment)
• Active central nervous system leukemia
• Known human immunodeficiency virus (HIV) seropositive, unless well-controlled on stable doses of anti-retroviral therapy
• Known hepatitis B surface antigen seropositive or known or suspected active hepatitis C infection Note: Patients who have isolated positive hepatitis B core antibody (ie, in the setting of negative hepatitis B surface antigen and negative hepatitis B surface antibody) must have an undetectable hepatitis B viral load. Patients who have positive hepatitis C antibody may be included if they have an undetectable hepatitis C viral load
• Patients with a prior or concurrent malignancy whose natural history or treatment is not anticipated to interfere with the safety or efficacy assessment of the investigational regimen may be included only after discussion with the PI
• Consumed strong inducer of CYP3A or p-glycoprotein within 14 days of study enrollment, or 5 half-lives, whichever is longer. Agents include but are not limited to: carbamazepine, phenytoin, rifampin, and St. John’s wart
• Treatment with any investigational antileukemic agents or chemotherapy agents in the last 7 days before study entry, unless full recovery from side effects has occurred or patient has rapidly progressive disease judged to be life-threatening by the investigator. Prior recent treatment with corticosteroids, hydroxyurea, cytarabine (up to 2 g/m2 given for cytoreduction within the preceding 7 days) and/or an Food and Drug Administration (FDA)-approved BCR::ABL1 TKI is permitted
• Inability to swallow
• Pregnant or breastfeeding women will not be eligible
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine, lisaftoclax, and olverembatinib or other agents used in study
• Patients with psychiatric illness/social situations that would limit compliance with study requirements