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Antibiotics After Radical Cystectomy and Urinary Diversion for the Prevention of Urinary Tract Infections in Patients with Muscle Invasive Bladder Cancer

Trial Status: active

This phase IV trial evaluates if not taking oral prophylactic antibiotics is as effective as taking oral prophylactic antibiotics in preventing urinary tract infections (UTI) after radical cystectomy with urinary diversion (postoperative) in patients with muscle invasive bladder cancer (MIBC). Standard treatment for MIBC is surgery to remove all of the bladder as well as nearby tissues and organs (radical cystectomy) along with making a new way for urine to leave the body (urinary diversion). UTI is one of the most common complications and the leading reason for readmission following radical cystectomy. Antibiotics are commonly used to prevent UTI in the postoperative setting (prophylactic). Long-term antibiotic use is associated with side effects, additional costs for patients, and destruction of protective organisms. Antibiotic use could potentially destroy protective organisms and cause an increase in UTI rates due to opportunistic organisms. Not taking oral prophylactic antibiotics may be as effective as taking oral prophylactic antibiotics in preventing postoperative UTI in patients with MIBC.