Registry for Esophageal and Gastroesophageal Junction Cancer

Inclusion Criteria

• * Newly diagnosed stage IV adenocarcinoma of the esophagus or GEJ with OMD at the time of diagnosis, defined as the following: ** Retroperitoneal lymph nodes (e.g., para-aortal, intra-aorto-caval, parapancreatic, or mesenterial lymph node) ** Liver ** Lung ** Extra-abdominal lymph nodes (e.g., supraclavicular or cervical lymph nodes) ** Adrenal gland ** Unilateral or bilateral ovarian metastases (in the absence of gross or microscopic peritoneal disease [positive cytology]) ** Bone * ≤ 2 sites of disease (excluding the primary tumor and regional lymph nodes) * ≤ 3 tumors within each organ system * ≤ 5 metastases ** All nonregional lymph nodes (including cervical, supraclavicular, and retroperitoneal nodal disease) are considered 1 discrete lesion ** Satellite lesions in the primary esophageal malignancy, such as skipped esophageal primaries, are not considered metastatic sites * All sites of disease must be amenable to complete local therapy after systemic therapy, according to the treating physician. Treatment modalities include: ** Surgery ** Definitive chemoradiation ** Stereotactic radiation ** Ablation or similar techniques (e.g., irreversible electroporation) * Age ≥ 18 years

Exclusion Criteria

• * Presence of metastases, at the time of diagnosis, to the following: ** Peritoneum, including positive peritoneal lavage (on the basis of baseline diagnostic laparoscopy to rule out gross disease and positive peritoneal lavage cytology; laparoscopy may be omitted for patients in whom all sites of disease are above the diaphragm) ** Malignant pleural effusion ** Brain metastases or leptomeningeal disease ** Other sites not specifically noted must be reviewed and approved by the PIs ** Any site of disease that is not amenable to definitive local therapy * Unfit for best systemic therapy * Metachronous OMD * Secondary primary cancer, with the exclusion of basal cell carcinoma of the skin * Pregnant, lactating, or intending to become pregnant * Unwilling to provide informed consent