Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE Study)
Trial Status: active
This study evaluates how women with mutations in BRCA1/2 genes may incorporate novel sources of ovarian cancer risk information into their decisions about cancer screening and risk reducing surgery. These novel sources of ovarian cancer risk information include polygenic risk scores (PRS), and multicancer early detection tests. A polygenic risk score is a summation of genetic modifiers, which each on its own has a tiny effect on cancer risk. However, as there are many genetic modifiers, all together they may impact BRCA1/2 associated risks.