A Psychoeducational Intervention to Reduce Psychological Distress and Improve Quality of Life for Patients with Newly Diagnosed Liver Cancer, HARMONY Trial

This clinical trial develops and tests a new coaching program that aims to provide education and support for reducing psychological distress (depressive and anxiety symptoms) and improving quality of life (QOL) for patients with newly diagnosed liver (hepatocellular) cancer. Despite different treatment approaches, patients diagnosed with all stages of hepatocellular cancer (HCC) face substantial challenges as they navigate the complex interplay between two associated life-altering illnesses – cancer and cirrhosis (severe scarring of the liver). HARMONY is a psychoeducational intervention which focuses on disease education to enhance self-efficacy for managing comorbid (presence of two or more diseases or conditions at the same time) serious illnesses, psychosocial skills to reduce prognostic distress, and self-compassion to reduce internalized stigma. Using the HARMONY intervention may help reduce psychological distress and improve QOL for patients with newly diagnosed liver cancer.

Additional locations may be listed on ClinicalTrials.gov for NCT06541990.

Trial PhaseNo phase specified

Trial Typesupportive care

Lead OrganizationDana-Farber Harvard Cancer Center

Principal InvestigatorKelsey See Wai Lau-Min

• Primary ID24-371
• Secondary IDsNCI-2024-07869
• ClinicalTrials.gov IDNCT06541990