Cirtuvivint and Olaparib for the Treatment of Patients with BRCA/HRD Platinum Resistant Ovarian Cancer

Inclusion Criteria

• Provision to sign and date the consent form
• Stated willingness to comply with all study procedures and be available for the duration of the study
• Woman aged ≥ 18 years of age
• Patients must have an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 1 or 2
• Patients must have a confirmed diagnosis of high-grade serous or endometrioid epithelial ovarian cancer (EOC), primary peritoneal cancer, or fallopian tube cancer
• Patients must have platinum-resistant disease defined as radiographic progression less than 6 months from last dose of most recent platinum therapy
• Patients must have measurable disease by defined Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria
• Prior anticancer therapy: * Patients must have received at least one prior platinum-based chemotherapy regimen * Patients may not have received more than 3 prior lines of systemic therapy * Neoadjuvant +/- adjuvant therapies are considered 1 line of therapy * Maintenance therapy (eg, Bevacizumab, PARP inhibitors) will be considered part of preceding line of therapy (ie, not counted independently) * Therapy changed due to toxicity in the absence of progression will be considered part of the same line (ie, not counted independently) * Hormonal therapy will be counted as a separate line of therapy unless it was given as maintenance * Prior radiation is allowed and is not considered a line of treatment
• Patients must have had testing for BRCA mutation (tumor or germline) and tumor HRD testing, and have been positive for one and/or the other
• Patients must have received a prior PARP inhibitor as either treatment or maintenance therapy
• Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L (1500/µL)
• Platelet count ≥ 100 x 10^9/L (100,000 µL)
• Hemoglobin ≥ 10.0 g/dL with no blood transfusion in the past 28 days
• Serum creatinine ≤ 1.5 x upper limit of normal (ULN)
• Patients must have creatinine clearance estimated of ≥ 51 mL/min using the Cockcroft-Gault equation or based on a 24 hour urine test
• Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) ≤ 2.5 x ULN unless liver metastases are present in which case they must be ≤ 5 x ULN
• Serum bilirubin ≤ 1.5 x ULN (patients with documented diagnosis of Gilbert syndrome are eligible if total bilirubin < 3.0 x ULN)
• Serum albumin ≥ 2 g/dL
• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
• Ability to understand and the willingness to sign a written informed consent document. Participants with impaired decision-making capacity (IDMC) who have a legally-authorized representative (LAR) and/or family member available will also be eligible

Exclusion Criteria

• Patients with clear cell, mucinous, sarcomatous, low grade/borderline, germ cell, or sex-cord stromal type ovarian tumor
• Patients with platinum refractory disease as defined by those who have progressed during or within 4 weeks of receiving platinum-based therapy
• Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within 3 weeks prior to study treatment
• Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)
• Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to: * Uncontrolled major seizure disorder * Unstable spinal cord compression * Any psychiatric disorder that prohibits obtaining informed consent * Any other concurrent infectious disease requiring intravenous (IV) antibiotics within 2 weeks prior to the first dose of therapy
• Patients with clinically significant cardiac disease including, but not limited to, any of the following: * Myocardial infarction ≤ 6 months prior to first dose * Uncontrolled ventricular arrhythmia, recent (within 3 months) * Superior vena cava syndrome * Unstable angina pectoris * Uncontrolled congestive heart failure (New York Heart Association > class II) * Uncontrolled ≥ grade 3 hypertension (per CTCAE) * Uncontrolled cardiac arrhythmias
• Patients with a history of hemorrhagic or ischemic stroke within 6 months prior to enrollment
• Patients with a history of cirrhotic liver disease (Child-Pugh Class B or C)
• Persistent toxicities (≥ Common Terminology Criteria for Adverse Event [CTCAE] grade 2) caused by previous cancer therapy, excluding alopecia or peripheral sensory neuropathy
• Patients with duodenal stent or other gastrointestinal (GI) disorder/defect that would interfere with absorption of oral medication * Includes patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the study medication
• Patients with known untreated or symptomatic central nervous system (CNS) metastases
• Prior known hypersensitivity reaction to study drugs and/or any of their excipients
• Minor or major surgical procedure within 2 weeks of starting study treatment and patients must have recovered from any effects of any major surgery
• Inability to comply with study and follow-up procedures
• Patients deemed otherwise clinically unfit for clinical trial per investigators discretion