A Study of JNJ-89402638 for Metastatic Colorectal Cancer

Inclusion Criteria

• Have histologically or cytologically confirmed diagnosis of colorectal adenocarcinoma (CRC) progressing after 2 or more prior lines of standard therapy in the metastatic/unresectable setting
• Have evaluable or measurable disease per response evaluation criteria in solid tumors (RECIST) version 1.1
• Part 1: Must have either measurable or evaluable disease
• Part 2: Must have at least 1 measurable lesion
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
• Have an estimated or measured glomerular filtration rate (GFR) greater than or equal to (>=) 30 milliliter per minute (mL/min) based on modification of diet in renal disease (MDRD) 4-variable formula

Exclusion Criteria

• Active (new or progressive) brain metastases, leptomeningeal disease, or untreated spinal cord compression
• Toxicity from prior anticancer therapy that has not resolved to Grade less than or equal to (<=)1 (except alopecia, vitiligo, Grade <= 2 peripheral neuropathy, or endocrinopathies that are stable on hormone replacement)
• Has a prior or concurrent second malignancy (other than the disease under study) unless natural history or treatment is unlikely to interfere with any study endpoints of safety or the efficacy of the study treatment
• Received glucocorticoids (doses >10 mg/day prednisone or equivalent) within 7 days prior to the first dose of study drug
• Received or plans to receive any live, attenuated vaccine within 4 weeks before the first dose of study treatment or within 4 weeks after the last dose of study treatment