Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Evaluating Penetrance of Anticancer Drugs in the Brain in Patients with Brain Cancer, ADePPT Trial

Trial Status: active

This phase I trial evaluates how effective certain drugs are at penetrating brain tumors in patients with primary brain cancer or solid tumor cancers that have spread beyond their original location to the brain (brain metastases) and who are planning to have a surgical procedure to have the brain tumor removed (resected) as part of their standard care. Some patients on this trial may also have a change (mutation) in their KRAS gene (KRAS G12C+). Usual treatment for patients with metastatic brain tumors require patients to undergo radiation therapy or surgery before receiving systemic therapies. This study wants to see how well treating patients with drugs before surgery works and evaluates drug activity in the brain. Giving drugs before surgery may work better in treating patients with metastatic brain cancer who are planning to have brain tumor surgery.