Perflutren Lipid Microspheres and Contrast Enhanced Ultrasound for the Improvement of Glioma Imaging During Brain Tumor Surgery
This phase I trial studies whether perflutren lipid microspheres and contrast enhanced ultrasound (CEUS) work to improve glioma imaging during brain tumor surgery. The goal of glioma brain tumor surgery is to remove as much of the glioma as possible. Tumor tissue that is close to normal brain tissue can look very similar. This can make it difficult for the surgeon to remove all the tumor. Contrast is a substance (also called an agent) that patients receive before certain imaging procedures. Contrast agents travel through the body to the area that will be imaged. The contrast agent causes the area of the body being imaged to be more visible to the clinician. An ultrasound is an imaging procedure that uses sound waves to take pictures of organs, tissues, and other structures inside the body and is routinely used in brain tumor surgery. A contrast agent that can be used during CEUS is perflutren lipid microspheres. Perflutren lipid microspheres contain tiny, gas-filled microbubbles. The bubbles are smaller than the size of blood cells. When sound waves from the ultrasound meet the contrast bubbles the bubbles vibrate and strongly reflect the sound waves. This creates a very light area on the image. This may improve glioma imaging and help the surgeon identify and remove all the glioma during brain tumor surgery.