This clinical trial evaluates the use of photoacoustic imaging (PAI) in patients with colon and rectal cancer. PAI is a technique during which non-radiation (non-ionizing) pulses are delivered into tissue and the resulting ultrasonic waves are detected and converted into images. For patients undergoing standard surgery, this trial may help researchers determine the ability of PAI in finding tumor density and formation of new blood vessels around the tumor. For patients who have received standard medication and radiation therapy, this trial may help researchers determine if PAI can tell the difference between tumors completely eliminated by treatment versus those that still partially remain.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04339374.
Locations matching your search criteria
United States
Missouri
Saint Louis
Siteman Cancer Center at Washington UniversityStatus: Active
Contact: William C. Chapman
Phone: 314-454-7177
PRIMARY OBJECTIVES:
I. To measure PAI and photoacoustic microscopy (PAM) signature from ex vivo colon tumor samples.
II. To characterize and correlate the tissue images with pathologic diagnosis.
III. To refine the imaging system and algorithms based on the characteristic features of ex vivo tissue study.
IV. To compare ex vivo imaging characteristics with in vivo images captured with endorectal coregistered photoacoustic probe.
V. To retrospectively review patients magnetic resonance imaging (MRI) data of pre-treatment and re-staging before surgery to establish a baseline of standard of care MRI based treatment prediction and assess improvement of additional PAI and PAM on treatment prediction.
OUTLINE: Patients are assigned to 1 of 2 arms.
ARM I: Patients undergo standard of care (SOC) surgical resection and have their resected tumor specimen undergo PAI immediately following surgery on study.
ARM II: Patients with distal colorectal tumors undergoing SOC surgical resection undergo PAI with a coregistered endorectal ultrasound probe over 20 minutes prior to SOC surgery. Patients then have their resected tumor specimen undergo PAI immediately following surgery on study. Patients with distal colorectal tumors undergoing SOC active surveillance undergo PAI with a coregistered endorectal ultrasound probe over 20 minutes during SOC endoscopic procedures (approximately every 4-6 months for 2 years).
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationSiteman Cancer Center at Washington University
Principal InvestigatorWilliam C. Chapman
