Telehealth Exercise Program to Improve Cancer Related Fatigue for Rural Breast or Prostate Cancer Survivors

Inclusion Criteria

• Age ≥ 18 and < 90 years of age
• Diagnosis of breast or prostate cancer
• Completion of treatment with curative intent > 3 months prior to and < 5 years from study initiation
• Treatment must include hormonal, radiation, chemotherapy, and/or immunotherapy. Those who have received only surgery are not eligible
• Individuals diagnosed with breast cancer currently receiving maintenance hormonal therapy, with no planned treatment changes in the next six months, are eligible
• Home zip code meeting Health Resources & Services Administration (HRSA) definition of rural
• Presence of at least moderate fatigue (> 3/10 per National Comprehensive Cancer Network guidelines)
• Access to high-speed home internet
• Possession of smartphone or laptop with front-facing camera
• Capable and willing to give informed consent
• Willing to participate in a 12-week telehealth exercise intervention or 12-week waiting period prior to intervention with brief remote physical assessments and dried blood spot collection every 2 weeks
• Able and willing to provide contact information for a local support individual to assist with any possible adverse events
• Able and willing to provide contact information for a local primary care provider to address medical issues potentially arising during study activities
• Able to provide signed physician clearance for exercise if indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) or National Comprehensive Cancer Network exercise safety screening questions

Exclusion Criteria

• Eastern Cooperative Oncology Group (ECOG) performance status grade ≥ 2
• Current or planned cancer-related treatments (except maintenance hormonal therapies) in the next six months. * For individuals with a prostate cancer diagnosis, those currently receiving androgen deprivation therapy (ADT), or those who have previously received ≥ 12 months of ADT, are not eligible
• Plans to relocate to a non-rural location in the next six months
• Presence of a disease or condition that affects the ability of an individual to safely participate in an exercise intervention (e.g. recent cardiac event or chronic obstructive pulmonary disease). * These conditions are regularly screened for in cancer survivors joining the BfitBwell Cancer Exercise Program and are identified in the PAR-Q+
• Presence or history of metabolic disease (e.g. diabetes or uncontrolled hyper- or hypothyroidism). * Participants with pre-diabetes, metabolic syndrome, or diabetes managed with metformin only will be eligible, with this variable tracked for later analysis
• Current participation in another exercise oncology program