Belumosudil Whole Tablets versus Crushed Tablets to Assess Appropriate Drug Levels in Patients with Chronic Graft versus Host Disease
This phase I trial compares the drug levels when taking belumosudil in whole tables versus when crushed in patients with chronic graft versus host disease. Acute and chronic graft-versus-host disease (GVHD) pose a significant challenge for patients undergoing hematopoietic stem cell transplant. Sometimes the transplanted cells from a donor can attack the body's normal cells (called graft-versus-host disease). Giving belumosudil after the transplant may stop this from happening. Belumosudil tablet needs to be swallowed whole and should not be crushed our chewed. However, when patients are not able to swallow a whole tablet, which can happen as a result of the transplant side effects or GVHD, crushing the tablet and putting it in water may be the only mechanism of administering belumosudil to these patients. It is not yet known if crushing the tablets and putting it in water changes the drug levels for patients receiving belumosudil for chronic GVHD.