Lisinopril for the Prevention of Urinary Side Effects Following Radiation Therapy in Patients with Prostate Adenocarcinoma
This phase I trial studies the side effects and best dose of lisinopril for the prevention of urinary side effects following radiation therapy for prostate adenocarcinoma. Radiation therapy is often used for the treatment of prostate adenocarcinoma. Although it is highly effective for controlling prostate cancer, radiation therapy can injure the bladder and urethra, causing acute and late side effects that may last for many years, and sometimes never completely go away. Lisinopril is a type of angiotensin-converting enzyme inhibitor used to treat high blood pressure and certain heart conditions. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict (narrow). This may improve blood flow to the urinary system, which may help prevent urinary side effects following radiation therapy for prostate adenocarcinoma.