Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Inclusion Criteria

• At least 18 years old and has provided informed consent.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Pathologically documented, locally advanced or metastatic KRAS G12V-mutated solid tumor malignancy.
• Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage.
• Measurable per RECIST v1.1
• Adequate organ function (bone marrow, liver, kidney, coagulation).
• Able to take oral medications.

Exclusion Criteria

• Primary central nervous system (CNS) tumors
• Prior therapy with KRAS G12V inhibitor or direct RAS-targeted therapy (eg. degraders and/or inhibitors).
• Any conditions that may affect the ability to take or absorb study drug.
• Major surgery within 28 days prior to receiving study drug(s).
• Patient is unable or unwilling to comply with protocol-required study visits or procedures.