Ultra-High Frequency Ultrasound with Indocyanine Green Dye for Characterization of Lymphatic Anatomy in Patients with Breast Cancer Undergoing Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy

This clinical trial tests the usefulness of indocyanine green dye with ultra-high frequency ultrasound for assessing lymphatic anatomy in patients with breast cancer undergoing axillary lymph node dissection or sentinel lymph node biopsy. Indocyanine green (ICG) is the current clinical standard of care for lymphatic mapping of the arms and legs to identify lymphatic structures (anatomy). Ultrasound is also routinely used for mapping of lymphatic vessels in patients undergoing lymphatic surgery. The difference in this study is that ultrasound with ICG will be used to map healthy lymphatic vessels in subjects without lymphedema to better understand what normal anatomy looks like on ultrasound and evaluate any side effects of ICG.

Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT07677839.

Trial PhaseNo phase specified

Trial Typesupportive care

Lead OrganizationUniversity of California Davis Comprehensive Cancer Center

Principal InvestigatorAra Salibian

• Primary ID2287319-1
• Secondary IDsNCI-2026-04264
• ClinicalTrials.gov IDNCT07677839