Clinical Trials Using Leuprolide Acetate

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Leuprolide Acetate. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-18 of 18
  • Hormone Therapy with or without Everolimus in Treating Patients with Breast Cancer

    This randomized phase III trial studies how well hormone therapy when given together with or without everolimus work in treating patients with breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate, goserelin acetate, leuprolide acetate, anastrozole, letrozole, or exemestane, may fight breast cancer by lowering the amount of estrogen the body makes. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether hormone therapy is more effective when given with or without everolimus in treating breast cancer.
    Location: 1374 locations

  • Antiandrogen Therapy and Radiation Therapy with or without Docetaxel in Treating Patients with Prostate Cancer That Has Been Removed by Surgery

    This randomized phase II / III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer that has been removed by surgery. Androgen can cause the growth of prostate cells. Antihormone therapy may lessen the amount of androgen made by the body. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving antiandrogen therapy and radiation therapy with or without docetaxel after surgery may kill any remaining tumor cells.
    Location: 181 locations

  • Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)

    The purpose of this study is to assess enzalutamide plus leuprolide in patients with high-risk nonmetastatic prostate cancer progressing after radical prostatectomy or radiotherapy or both.
    Location: 12 locations

  • Apalutamide, Abiraterone Acetate, Prednisone, Leuprolide Acetate, and Stereotactic, Ultra-hypofractionated Radiation Therapy in Treating Patients with Very High Risk Prostate Cancer

    This phase II trial studies how well apalutamide, abiraterone acetate, prednisone, leuprolide acetate, and stereotactic, ultra-hypofractionated radiation therapy work in treating patients with very high risk prostate cancer. Hormone therapy using apalutamide, abiraterone acetate, prednisone, and leuprolide acetate may fight prostate cancer by lowering the amount of androgen the body makes and / or blocking the use of androgen by the tumor cells. Stereotactic, ultra-hypofractionated radiation therapy is a type of radiation therapy delivers higher doses of radiation over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving apalutamide, abiraterone acetate, prednisone, and leuprolide acetate, and stereotactic, ultra-hypofractionated radiation therapy may work better in treating patients with prostate cancer.
    Location: 8 locations

  • Stereotactic Body Radiation Therapy and Hormone Therapy in Treating Patients with Localized Intermediate-Risk Prostate Cancer

    This phase I / II trial studies the side effects of stereotactic body radiation therapy (SBRT), also known as stereotactic radiosurgery, and hormone therapy and how well they work in treating patients with localized intermediate-risk prostate cancer. SBRT is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor cells and cause less damage to normal tissue. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin acetate, leuprolide acetate, and bicalutamide, may lessen the amount of androgens made by the body. Giving SBRT and hormone therapy may be an effective treatment for prostate cancer.
    Location: 4 locations

  • Abiraterone Acetate and Apalutamide before and after Surgery in Treating Patients with Intermediate-High Risk Prostate Cancer

    This phase II trial studies how well abiraterone acetate and apalutamide work in treating patients with intermediate-high risk prostate cancer before and after surgery. Androgens can cause the growth of prostate cancer cells. Drugs, such as abiraterone acetate and apalutamide, may lessen the amount of androgens made by the body.
    Location: 3 locations

  • Androgen Deprivation Therapy, Docetaxel, External Beam Radiation Therapy, and Stereotactic Body Radiation Therapy in Treating Patients with Prostate Cancer

    This phase II trial studies the side effects of androgen deprivation therapy, docetaxel, external beam radiation therapy, and stereotactic body radiation therapy work in treating patients with prostate cancer. Androgen deprivation therapy, such as leuprolide acetate, triptorelin, degarelix, and bicalutamide may lessen the amount of androgen made by the body. Drugs used in the chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External beam radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the tumor using smaller doses over several days and may cause less damage to normal tissue. Giving androgen deprivation therapy, docetaxel, external beam radiation therapy, and stereotactic body radiation therapy may work better in treating patients with prostate cancer.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Apalutamide with or without Abiraterone Acetate, Gonadotropin-Releasing Hormone Analog, and Prednisone in Treating Patients with High-Risk Prostate Cancer Undergoing Surgery

    This randomized phase II trial studies how well apalutamide works with or without abiraterone acetate, gonadotropin-releasing hormone agonist, and prednisone in treating patients with high-risk prostate cancer undergoing surgery. Androgen can cause the growth of prostate cancer cells. Hormone therapy using apalutamide, abiraterone acetate, and gonadotropin-releasing hormone analog (GnRH agonist) may fight prostate cancer by lowering the levels of androgen the body makes. Prednisone may either kill the tumor cells or stop them from dividing. Giving apalutamide with or without abiraterone acetate, GnRH agonist and prednisone may work better in treating patients with prostate cancer.
    Location: 2 locations

  • Androgen Receptor Antagonist ARN509 and Leuprolide Acetate in Treating Patients with Prostate Cancer before Surgery

    This phase II trial studies how well androgen receptor antagonist ARN-509 and leuprolide acetate work in treating patients with prostate cancer before surgery. Hormone therapy using androgen receptor antagonist ARN-509 and leuprolide acetate may fight prostate cancer by lowering the amount of androgen the body makes and / or blocking the use of androgen by the tumor cells.
    Location: Case Comprehensive Cancer Center, Cleveland, Ohio

  • Hormone Therapy and Docetaxel before Surgery and Radiation Therapy in Treating Patients with Newly Diagnosed Oligometastatic Prostate Cancer

    This phase II trial studies the side effects of hormone therapy and docetaxel before surgery and radiation therapy in treating patients with newly diagnosed prostate cancer that has spread from the primary tumor through the body to form a small number of new tumors in one or two other parts of the body. Androgens are a type of hormone that can cause the growth of prostate cancer cells. Androgen deprivation therapy, stops the growth of tumor cells by lessening the amount of androgens made by the body. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving androgen deprivation therapy and chemotherapy before radical prostatectomy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving radiation therapy after surgery may kill any remaining tumor cells. Stereotactic body radiation therapy is a specialized radiation therapy that delivers a single, high dose of radiation directly to the metastatic sites and may kill more tumor cells and cause less damage to normal tissue. Giving androgen deprivation therapy and chemotherapy before surgery and SBRT may work better in treating patients with newly diagnosed oligometastatic prostate cancer.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Enzalutamide and Leuprolide Acetate after Radiation Therapy in Treating Patients with High-Risk Prostate Cancer

    This phase II trial studies the safety of giving enzalutamide with leuprolide acetate after radiation therapy and to see how well it works in treating patients with prostate cancer that is at high risk of returning. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Most types of prostate cancer also need testosterone to grow and spread. After radiation therapy, patients often receive treatments to reduce testosterone to prevent the cancer from returning. Leuprolide acetate works by reducing the amount of testosterone that the body makes. Enzalutamide is a stronger treatment that may block testosterone from reaching cancer cells. Adding enzalutamide to treatment with leuprolide acetate after radiation therapy may help prevent high-risk prostate cancer from returning and improve patient survival.
    Location: UCSF Medical Center-Mount Zion, San Francisco, California

  • High-Dose Brachytherapy in Treating Patients with Prostate Cancer

    This phase I / II trial studies the side effects and how well high-dose brachytherapy works in treating patients with prostate cancer that has not spread to other parts of the body. Brachytherapy is a type of radiation therapy in which radioactive material sealed in needles, seeds, wires, or catheters is placed directly into or near a tumor and may be a better treatment in patients with prostate cancer.
    Location: Stanford Cancer Institute Palo Alto, Palo Alto, California

  • Testosterone Therapy Followed by Enzalutamide or Abiraterone Acetate in Treating Patients with Prostate Cancer That Is Progressing on Combined Androgen Therapies

    This phase II trial studies how well testosterone therapy followed by enzalutamide or abiraterone acetate works in treating patients with prostate cancer that has become worse or spread on combined androgen therapies. Androgens, such as testosterone, can cause the growth of prostate cancer cells. Androgen therapies, such as enzalutamide and abiraterone acetate, suppress or block the production or action of testosterone. Rapid treatment with testosterone may make the cancer cells become sensitive to retreatment with enzalutamide or abiraterone acetate. Giving testosterone prior to enzalutamide or abiraterone acetate may have an effect on the growth of prostate cancer in men who have not responded to long term therapy to lower testosterone in their blood (castrating therapy).
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Enzalutamide and Leuprolide Acetate before, during, and after Radiation Therapy in Treating Patients with High-Risk Localized or Locally Advanced Prostate Cancer

    This pilot phase II trial studies the side effects and how well enzalutamide and leuprolide acetate before, during, and after radiation therapy work in treating patients with prostate cancer that is very likely to spread from where it started or has already spread to nearby tissue or lymph nodes. Androgens can cause the growth of prostate cancer cells. Drugs, such as enzalutamide and leuprolide acetate, may lessen the amount of androgens made by the body. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving enzalutamide and leuprolide acetate before, during, and after radiation therapy may be an effective treatment for prostate cancer.
    Location: UT Southwestern / Simmons Cancer Center-Dallas, Dallas, Texas

  • Intensity Modulated Radiation Therapy with Stereotactic Radiosurgery Boost and Hormone Therapy in Treating Patients with Prostate Cancer

    This clinical trial studies intensity modulated radiation therapy (IMRT) with stereotactic radiosurgery boost and hormone therapy in treating patients with prostate cancer. Specialized radiation therapy, such as IMRT and stereotactic radiosurgery, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Androgen hormones can cause the growth of prostate cancer cells and antihormone therapy drugs, such as leuprolide acetate, goserelin acetate, and bicalutamide, may lessen the amount of androgens made by the body. Giving IMRT with stereotactic radiosurgery boost and androgen deprivation therapy may be an effective treatment for prostate cancer.
    Location: University of California Davis Comprehensive Cancer Center, Sacramento, California

  • Androgen Deprivation Therapy, Pembrolizumab, and High Dose Rate Brachytherapy with or without TLR9 Agonist SD-101 in Treating Patients with Metastatic Prostate Cancer

    This randomized phase II trial studies how well androgen deprivation therapy, pembrolizumab, and high dose rate brachytherapy with or without TLR9 agonist SD-101 in treating patients with prostate cancer that has spread to other places in the body. Androgen can cause the growth of tumor cells. Androgen deprivation therapy, such as leuprolide acetate and bicalutamide, may lessen the amount of androgen made by the body. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Colony-stimulating factors, such as TLR9 agonist SD-101, may increase the production of blood cells. It is not yet know whether giving androgen deprivation therapy, pembrolizumab, and high dose rate brachytherapy with or without TLR9 agonist SD-101 may work better in treating patients with prostate cancer.
    Location: UCSF Medical Center-Mount Zion, San Francisco, California

  • Enzalutamide versus Standard Androgen Deprivation Therapy in Reducing Incidence of Metabolic Syndrome in Patients with Advanced Prostate Cancer

    This randomized phase II trial compares enzalutamide with standard androgen deprivation therapy in reducing incidence of metabolic syndrome in patients with prostate cancer that has spread to other places in the body. Metabolic syndrome is defined as changes in cholesterol, blood pressure, circulating sugar levels, and body weight. Previous studies have shown that patients with prostate cancer, who have been treated with standard medical therapy that lowers testosterone levels, have an increased risk of these changes. Hormone therapy using enzalutamide may fight prostate cancer by blocking the use of testosterone by the tumor cells instead of lowering testosterone levels. It is not yet known whether prostate cancer patients who receive enzalutamide will have reduced incidence of metabolic syndrome than patients who receive standard androgen deprivation therapy.
    Location: 2 locations

  • Palifermin with Leuprolide Acetate after Total-Body Irradiation Based Donor Stem Cell Transplant in Treating Patients with Hematologic Malignancies

    This phase II trial studies how well giving palifermin with leuprolide acetate works after total body-irradiation based donor stem cell transplant in treating patients with hematologic malignancies. Giving chemotherapy and total body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving palifermin and leuprolide acetate and removing the T cells from the donor cells before transplant may stop this from happening. It is not yet known whether giving palifermin with leuprolide is more effective in helping the immune system recover faster after a donor stem cell transplant.
    Location: Memorial Sloan-Kettering Cancer Center, New York, New York