Clinical Trials Using Nelarabine

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Nelarabine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Risk Classification Schemes in Identifying Better Treatment Options for Children and Adolescents with Acute Lymphoblastic Leukemia

    This randomized phase III trial studies risk classification schemes in identifying better treatment options for children and adolescents with acute lymphoblastic leukemia. Risk factor classification may help identify how strong treatment should be for patients with acute lymphoblastic leukemia.
    Location: 5 locations

  • CXCR4 Antagonist BL-8040 and Nelarabine in Treating Patients with Relapsed or Refractory T-Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

    This pilot phase IIa clinical trial studies the side effects of CXC chemokine receptor 4 (CXCR4) antagonist BL-8040 and nelarabine in treating patients with T-acute lymphoblastic leukemia or lymphoblastic lymphoma that has either come back after treatment or has not responded to treatment at all. Drugs used in chemotherapy, such as CXCR4 antagonist BL-8040 and nelarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 2 locations

  • Panobinostat, Bortezomib, and Vincristine Sulfate Liposome with Re-induction Therapy in Treating Younger Patients with Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia or Lymphoma

    This phase II trial studies how well panobinostat, bortezomib, and vincristine sulfate liposome and re-induction therapy (strong chemotherapy) work in treating younger patients with T-cell acute lymphoblastic leukemia or lymphoma that has returned (relapsed) or does not respond to treatment (refractory). Panobinostat and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as mitoxantrone hydrochloride, pegaspargase, dexamethasone, cytarabine, vincristine sulfate liposome, methotrexate, mercaptopurine, nelarabine, cyclophosphamide, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving panobinostat, bortezomib, and vincristine sulfate liposome together with re-induction therapy may kill more cancer cells.
    Location: St. Jude Children's Research Hospital, Memphis, Tennessee

  • Combination Chemotherapy and Nelarabine in Treating Patients with T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

    This phase II trial studies the side effects and how well combination chemotherapy and nelarabine work in treating patients with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, dexamethasone, methotrexate, cytarabine, mercaptopurine, prednisone, pegaspargase, and nelarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: M D Anderson Cancer Center, Houston, Texas