Clinical Trials Using Plerixafor

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Plerixafor. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-7 of 7
  • Scleroderma Treatment with Autologous Transplant (STAT) Study

    This phase II trial studies how well giving cyclophosphamide and anti-thymocyte globulin together followed by peripheral blood stem cell transplant (PBSCT) and mycophenolate mofetil works in treating patients with systemic scleroderma (SSc). Stem cells are collected from the patient's blood and stored prior to treatment. To store the stem cells patients are given colony-stimulating factors, such as filgrastim (G-CSF) or chemotherapy (cyclophosphamide) to help stem cells move from the bone marrow to the blood so they can be collected and stored. After storage, patients are then given high-dose chemotherapy, cyclophosphamide, and immunosuppression with anti-thymocyte globulin to suppress the immune system to prepare for the transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and immunosuppression. After the stem cells have “engrafted” and have matured enough to support the immune system at approximately 2-3 months, patients are given a medication called mycophenolate mofetil (MMF) or Myfortic. This medication is given to prevent worsening or reactivation of SSc and is referred to as maintenance therapy.
    Location: 14 locations

  • HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients with Lymphoma with HIV Infection

    This pilot phase I trial studies the side effects and best dose of human immunodeficiency virus (HIV)-resistant gene modified stem cells in treating HIV-positive patients who are undergoing first-line treatment for Hodgkin or Non-Hodgkin Lymphoma. Stem cells are collected from the patient and HIV-resistance genes are placed into the stem cells. The stem cells are then re-infused into the patient. These genetically modified stem cells may help the body make cells that are resistant to HIV infection.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Gene Therapy for Fanconi Anemia

    This pilot clinical trial will access the toxicity and efficacy of infusion of gene modified cells for patients with Fanconi anemia (FA). Infusion of autologous patient blood stem cells that have been corrected in the laboratory by introduction of the normal gene may improve blood counts in patients with FA.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR after a Myeloablative Conditioning Regimen to Treat Patients with Advanced Cancer

    This phase I clinical trial evaluates the safety and feasibility of administering NY-ESO-1 TCR engineered peripheral blood mononuclear cells (PBMC) and peripheral blood stem cells (PBSC) after a myeloablative conditioning regimen to treat patients with cancer that has spread to other parts of the body. The conditioning chemotherapy makes room in the patient’s bone marrow for new blood cells (PBMC) and blood-forming cells (stem cells) to grow. Giving NY-ESO-1 TCR PBMC and stem cells after the conditioning chemotherapy is intended to replace the immune system with new immune cells that have been redirected to attack and kill the cancer cells and thereby improve immune system function against cancer.
    Location: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

  • Plerixafor and Bevacizumab in Treating Patients with Recurrent High-Grade Glioma

    This phase I trial studies the side effects and best dose of plerixafor when given together with bevacizumab in treating patients with high-grade glioma that has come back after a period of improvement. Plerixafor may stimulate the immune system in different ways and stop tumor cells from growing. Monoclonal antibodies, such as bevacizumab, may block tumor growth in different ways by targeting certain cells. Giving plerixafor together with bevacizumab may kill more tumor cells.
    Location: 4 locations

  • Plerixafor in Increasing CD34+ Hematopoietic Progenitor Cells in Patients with Sickle Cell Disease

    This phase I trial studies the side effects and the best dose of plerixafor in increasing cluster of differentiation 34 (CD34) blood forming cell (hematopoietic progenitor cell) count in patients with sickle cell disease. Plerixafor may help move CD34 cells from the bone marrow to the blood. These cells are then collected, changed in the laboratory to make normal oxygen carrying molecules (hemoglobin) in red blood cells and then given back to the patient.
    Location: 3 locations

  • Access Program for Use of AMD3100 to Increase Peripheral Blood Stem Cells for Transplantation in Patients Who Have Failed Standard Therapy Stem Cell Mobilization

    The purpose of this program is to provide access to AMD3100 for patients who would benefit from an autologous stem cell transplant but who have either previously failed to collect enough cells for transplant following standard therapy or are not considered by their physician to have a reasonable chance of collecting enough cells for transplant.
    Location: Location information is not yet available.