Clinical Trials Using Aminolevulinic Acid Hydrochloride

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Aminolevulinic Acid Hydrochloride. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-5 of 5
  • Photodynamic Therapy and Vismodegib in Treating Patients with Multiple Basal Cell Cancers

    This phase I trial studies the side effects and best way to give photodynamic therapy together with vismodegib in treating patients with multiple basal cell cancers. Photodynamic therapy uses a drug, such as aminolevulinic acid that becomes active when it is exposed to light. The activated drug may kill tumor cells. Vismodegib may stop the growth of tumor cells by blocking a type of protein involved in tissue growth. Giving photodynamic therapy with vismodegib may be a better treatment for basal cell cancer.
    Location: The University of Arizona Medical Center-University Campus, Tucson, Arizona

  • Photodynamic Therapy Using Blue Light or Red Light in Treating Basal Cell Carcinoma in Patients with Basal Cell Nevus Syndrome

    This pilot randomized phase II trial studies how well photodynamic therapy using blue light or red light works in treating basal cell cancer (carcinoma) in patients with a genetic condition that causes unusual facial features and disorders of the skin, bones, nervous system, eyes, and endocrine glands, also called basal cell nevus syndrome. Photodynamic therapy uses drugs, such as aminolevulinic acid hydrochloride, that are taken up by tumor cells and when exposed to an intensive light source (blue light or red light) become active and may kill the cells. It is not yet known whether photodynamic therapy is more effective with blue light or red light in treating basal cell carcinoma.
    Location: Cleveland Clinic Foundation, Cleveland, Ohio

  • Aminolevulinic Acid Hydrochloride and Photodynamic Therapy in Preventing Actinic Keratosis and Non-melanoma Skin Cancer in Patients Who Have Undergone Solid Organ Transplant

    This pilot phase II trial studies the side effects of aminolevulinic acid hydrochloride and photodynamic therapy and to see how well they work in preventing actinic keratosis and non-melanoma skin cancer in patients who have undergone a solid organ transplant. Photodynamic therapy uses a drug, such as aminolevulinic acid hydrochloride, that becomes active when it is exposed to light. The activated drug may kill tumor cells.
    Location: Arizona Cancer Center-Phoenix Campus, Phoenix, Arizona

  • Imaging Procedure Using Aminolevulinic Acid Hydrochloride in Finding Residual Tumor in Patients with Grade IV Malignant Gliomas Who Are Undergoing Surgery

    This randomized phase II trial studies the best dose of aminolevulinic acid hydrochloride when given before an imaging procedure in finding residual tumor in patients with grade IV malignant gliomas who are undergoing surgery. Imaging procedures that use aminolevulinic acid hydrochloride may help find and diagnose residual tumor in patients with grade IV malignant gliomas who are undergoing surgery to remove the tumor.
    Location: Case Comprehensive Cancer Center, Cleveland, Ohio

  • Aminolevulinic Acid Hydrochloride in Visualizing Tumors in Patients with Newly Diagnosed or Recurrent Malignant Gliomas Undergoing Surgery

    This phase II trial studies how well aminolevulinic acid hydrochloride works in visualizing tumors in patients with newly diagnosed malignant gliomas or malignant gliomas that have returned after a period of improvement who are undergoing surgery. Aminolevulinic acid hydrochloride is a fluorescent substance that can make tumor cells glow under a microscope with a special blue light that may help visualize and remove as much tumor as possible without harming healthy tissue.
    Location: 4 locations