Clinical Trials Using Vandetanib

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Vandetanib. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Cisplatin or Carboplatin and Etoposide With or Without Vandetanib in Treating Patients With Previously Untreated Extensive Stage Small Cell Lung Cancer or High-Grade or Poorly Undifferentiated Neuroendocrine Cancer

    This randomized phase II trial studies how well cisplatin or carboplatin and etoposide with or without vandetanib works in treating patients with previously untreated extensive stage small cell lung cancer or high-grade or poorly differentiated neuroendocrine cancer. Drugs used in chemotherapy, such as cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving cisplatin or carboplatin and etoposide is more effective with or without vandetanib in treating small cell lung cancer or neuroendocrine cancer.
    Location: 2 locations

  • Vandetanib and Metformin Hydrochloride in Treating Patients with Advanced Kidney Cancer

    This phase I / II trial studies the side effects and best dose of metformin hydrochloride when given together with vandetanib and to see how well they work in treating patients with kidney cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment. Vandetanib and metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: National Institutes of Health Clinical Center, Bethesda, Maryland

  • Vandetanib in Treating Patients with Breast Cancer

    This randomized phase II trial studies how well vandetanib works in treating patients with breast cancer. Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: University of Iowa / Holden Comprehensive Cancer Center, Iowa City, Iowa

  • Vandetanib and Everolimus in Treating Patients with Advanced or Metastatic Cancer

    This phase I trial studies the side effects and best dose of vandetanib and everolimus when given together in treating patients with cancer that has spread to other places in the body. Vandetanib and everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
    Location: M D Anderson Cancer Center, Houston, Texas