Clinical Trials Using Topotecan Hydrochloride

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Topotecan Hydrochloride. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-25 of 31
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  • Trametinib in Treating Patients with Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer

    This randomized phase II / III trial studies how well trametinib works and compares it to standard treatment with either letrozole, tamoxifen citrate, paclitaxel, pegylated liposomal doxorubicin hydrochloride, or topotecan hydrochloride in treating patients with low-grade ovarian cancer or peritoneal cavity cancer that has come back, become worse, or spread to other parts of the body. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether trametinib is more effective than standard therapy in treating patients with ovarian or peritoneal cavity cancer.
    Location: 461 locations

  • PH3 Study of Mirvetuximab Soravtansine vs Investigator's Choice of Chemotherapy in Women With FRa+ Adv. EOC, Primary Peritoneal or Fallopian Tube Cancer

    This is a Phase 3, open label, randomized study designed to compare the safety and efficacy of IMGN853 to that of selected single-agent chemotherapy (Investigator's choice) in women with platinum-resistant FR-alpha positive advanced EOC, primary peritoneal cancer and / or fallopian tube cancer.
    Location: 12 locations

  • Alisertib Alone or in Combination with Chemotherapy and Radiation Therapy in Treating Younger Patients with Recurrent, Progressive, or Newly Diagnosed Central Nervous System Atypical Teratoid Rhabdoid Tumors or Extra-Central Nervous System Malignant Rhabdoid Tumors

    This phase II trial studies how well alisertib alone or in combination with chemotherapy and radiation therapy works in treating younger patients with central nervous system (CNS) atypical teratoid rhabdoid tumors that are newly diagnosed; have returned; or are growing, spreading, or getting worse or extra-CNS malignant rhabdoid tumors that have returned or are growing, spreading, or getting worse. Alisertib may stop the growth of cancer cells by blocking a protein called aurora kinase A that is needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses x-rays to kill tumor cells. Giving alisertib alone or with chemotherapy and radiation therapy may be effective in treating patients with rhabdoid tumors.
    Location: 10 locations

  • Veliparib and Topotecan Hydrochloride in Treating Patients with Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer

    This phase I / II trial studies the side effects and best dose of veliparib and topotecan hydrochloride and to see how well they work in treating patients with solid tumors, ovarian cancer that has come back or does not respond to treatment, or primary peritoneal cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving veliparib with chemotherapy may kill more tumor cells.
    Location: 11 locations

  • Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments.

    Comparison of olaparib vs. physician's choice of single agent standard of care non-platinum based chemotherapy in patients with germline Breast Cancer susceptibility gene (gBRCA) mutated ovarian cancer who have progressed at least 6 months after the last platinum based chemotherapy. Patient should have received at least 2 prior lines of platinum based chemotherapy. The aim of the study is to assess the efficacy and safety of olaparib tablets.
    Location: 6 locations

  • Selinexor with Multiple Standard Chemotherapy Regimens in Treating Patients with Advanced Malignancies

    This phase Ib trial studies the side effects and best dose of selinexor when given together with several different standard chemotherapy regimens in treating patients with malignancies that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Selinexor may stop the growth of cancer cells by blocking enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Studying selinexor with different standard chemotherapy regimens may help doctors learn the side effects and best dose of selinexor that can be given with different types of treatments in one study.
    Location: 5 locations

  • Sorafenib and Cyclophosphamide / Topotecan in Patients With Relapsed and Refractory Neuroblastoma

    This study will combine three drugs: sorafenib, cyclophosphamide and topotecan. Adding sorafenib to cyclophosphamide and topotecan may increase the effectiveness of this combination. The investigators first need to find out the highest dose of sorafenib that can be given safely together with cyclophosphamide and topotecan. This is the first study to test giving these three drugs together and will help determine the highest dose of sorafenib that can safely be given together with cyclophosphamide and topotecan to patients with resistant / relapsed neuroblastoma.
    Location: 5 locations

  • Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma

    The purpose of this study is to determine whether nifurtimox in combination with cyclophosphamide and topotecan are effective in the treatment of relapsed or refractory neuroblastoma and medulloblastoma.
    Location: 5 locations

  • Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients with Recurrent Glioblastoma Multiforme

    This phase II trial studies how well pazopanib hydrochloride and topotecan hydrochloride work in treating patients with glioblastoma multiforme that has come back (recurrent). Pazopanib hydrochloride and topotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving low doses of pazopanib hydrochloride and topotecan hydrochloride daily may work better in treating patients with glioblastoma.
    Location: 4 locations

  • Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)

    The purpose of this randomized, open-label, 2-arm, Phase 3 study is to assess the assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic Small Cell Lung Cancer (SCLC) with high levels of delta-like protein 3 (DLL3) and who have first disease progression during or following front-line platinum-based chemotherapy.
    Location: 4 locations

  • Clinical Trial of Lurbinectedin (PM01183) / Doxorubicin (DOX) Versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients With Small-Cell Lung Cancer

    Phase III randomized clinical trial of lurbinectedin (PM01183) / doxorubicin (DOX) versus cyclophosphamide (CTX), doxorubicin (DOX) and vincristine (VCR) (CAV) or topotecan as treatment in patients with small-cell lung cancer (SCLC) who failed one prior platinum-containing line to determine a difference in progression-free survival (PFS) by an Independent Review Committee (IRC) between lurbinectedin (PM01183) / doxorubicin (DOX) and the control arm (CAV) or topotecan and to analyze the median overall survival (OS) and mid- and long-term overall survival (OS at 12, 18 and 24 months).
    Location: 4 locations

  • Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

    This is a multi-institutional, randomized, open-label phase II study of pembrolizumab compared to topotecan, administered to patients with SCLC who have progressed or relapsed after first-line treatment with etoposide and platinum. Patients will be randomized in a 2:1 fashion to receive pembrolizumab or topotecan. Participants in the topotecan arm that progress will be allowed to cross-over to the pembrolizumab arm.
    Location: 3 locations

  • MV-NIS or Investigator's Choice Chemotherapy in Treating Patients with Ovarian, Fallopian, or Peritoneal Cancer

    This randomized phase II trial studies how well oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) compared to investigator's choice chemotherapy works in treating patients with ovarian, fallopian, or peritoneal cancer. Measles virus, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells.
    Location: 2 locations

  • Convection-Enhanced Delivery of Topotecan Hydrochloride in Treating Patients with Recurrent High Grade Glioma

    This phase Ib trial studies the side effects of convection-enhanced delivery of topotecan hydrochloride in treating patients with high grade glioma that has come back. Convection-enhanced delivery will directly infuse topotecan hydrochloride into the tumor and may help to avoid the side effects and achieve high levels of the drug directly into the tumor where it can be more effective.
    Location: Columbia University / Herbert Irving Cancer Center, New York, New York

  • Study of Lorlatinib (PF-06463922)

    Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in combination with chemotherapy in patients with relapsed / refractory neuroblastoma. The dose escalation phase of this study (Cohort A1) uses a traditional Phase I 3+3 design. Once a recommended phase 2 pediatric dose is identified, an expansion cohort of 6 patients (Cohort B1), within which ALKi naïve patients will be prioritized, will be initiated. Parallel cohorts will be initiated in adults or patients with large BSA (Cohort A2) and in combination with chemotherapy upon establishing RP2D (Cohort B2).
    Location: Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia

  • Dinutuximab and Irinotecan Versus Irinotecan to Treat Subjects With Relapsed or Refractory Small Cell Lung Cancer

    This is a 2-part, multicenter, open-label, randomized study of dinutuximab and irinotecan versus irinotecan alone in subjects with relapsed or refractory small cell lung cancer (SCLC). Part 1 of the study involves intrasubject dose escalation to evaluate the safety and tolerability of dinutuximab in combination with irinotecan. Part 2 of the study is designed to determine whether dinutuximab plus irinotecan prolongs overall survival (OS) compared with irinotecan alone. Subjects in Part 2 will be randomized in a 2:2:1 fashion to 1 of 3 treatment groups: (A) irinotecan; (B) dinutuximab plus irinotecan; or (C) topotecan. Randomization will be stratified by duration of response to prior platinum therapy (relapse-free period <3 months or ≥3 months).
    Location: 3 locations

  • Trilaciclib (G1T28), a CDK 4 / 6 Inhibitor, in Patients With Previously Treated Extensive Stage SCLC Receiving Topotecan Chemotherapy

    This is a study to investigate the potential clinical benefit of trilaciclib (G1T28) in preserving the bone marrow and the immune system, and enhancing chemotherapy antitumor efficacy when administered prior to topotecan in patients previously treated for extensive-stage SCLC. The study consists of 2 parts: a limited open-label, dose-finding portion (Part 1), and a randomized double-blind portion (Part 2). Both parts include 3 study phases: Screening Phase, Treatment Phase, and Survival Follow-up Phase. The Treatment Phase begins on the day of first dose with study treatment and completes at the Post-Treatment Visit. The open-label portion enrolled 32 patients and the randomized portion will enroll approximately 90 patients.
    Location: 2 locations

  • Topotecan Hydrochloride Using Convection-Enhanced Delivery in Treating Patients with Recurrent or Progressive High-Grade Glioma Undergoing Surgery

    This pilot clinical trial studies topotecan hydrochloride delivered directly to the brain using convection-enhanced delivery in treating patients with high-grade glioma that has come back (recurrent) or that is growing, spreading, or getting worse (progressed) undergoing surgery. Drugs used in chemotherapy, such as topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving topotecan hydrochloride directly into the brain via a catheter that bypasses the blood brain barrier may kill more tumor cells.
    Location: Case Comprehensive Cancer Center, Cleveland, Ohio

  • ATR Kinase Inhibitor VX-970 and Topotecan Hydrochloride in Treating Patients with Previously Treated Lung, Ovarian, Cervical, Neuroendocrine, or Small Cell Cancers

    This phase I / II trial studies the side effects and the best dose of ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor VX-970 (VX-970) when given together with topotecan hydrochloride and to see how well the combination works in treating patients with previously treated lung, ovarian, cervical, neuroendocrine, or small cell cancers. VX-970 may stop the growth of tumor cells by blocking a protein called ATR that is involved in deoxyribonucleic acid (DNA) repair. Drugs used in chemotherapy, such as topotecan hydrochloride, work by damaging the DNA in tumor cells. Giving VX-970 together with topotecan hydrochloride may be a better treatment for lung, ovarian, cervical, neuroendocrine, or small cell cancers.
    Location: National Institutes of Health Clinical Center, Bethesda, Maryland

  • Simvastatin, Topotecan Hydrochloride, and Cyclophosphamide in Treating Younger Patients with Relapsed and / or Refractory Solid and CNS Tumors

    This phase I trial studies the side effects and best dose of simvastatin when given together with topotecan hydrochloride and cyclophosphamide in treating younger patients with solid and central nervous system (CNS) tumors that have returned (relapsed) and / or that do not respond to treatment (refractory). Simvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan hydrochloride and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving simvastatin together with topotecan hydrochloride and cyclophosphamide may be a better treatment for solid and CNS tumors.
    Location: Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia

  • Avatar-Directed Chemotherapy in Treating Patients with Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

    This phase II trial studies how well Avatar-directed chemotherapy works in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that does not respond to platinum anti-cancer drugs. Drugs used in chemotherapy, such as paclitaxel, gemcitabine hydrochloride, pegylated liposomal doxorubicin hydrochloride, topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Using an Avatar, a living tumor sample with similar genetic characteristics to the original tumor, may help determine which chemotherapy is most effective.
    Location: Mayo Clinic, Rochester, Minnesota

  • Efficacy and Safety of Aldoxorubicin Compared to Topotecan in Subjects With Metastatic Small Cell Lung Cancer

    The purpose of this study is to evaluate the efficacy and safety of aldoxorubicin compared to topotecan in subjects with metastatic small cell lung cancer.
    Location: 2 locations

  • Combination Chemotherapy and Melphalan in Treating Younger Patients with Newly Diagnosed Advanced Intra-Ocular Retinoblastoma

    This pilot clinical trial studies the side effects and the best dose of a combination of chemotherapy and melphalan or melphalan alone in treating younger patients newly diagnosed with retinoblastoma within the eyeball (intra-ocular) that has spread to other places in the body and usually cannot be cured or controlled with treatment. Drugs used in chemotherapy, such as carboplatin, etoposide, vincristine sulfate, and melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The treatment for intra-ocular retinoblastoma is either a standard combination of carboplatin, etoposide, and vincristine sulfate chemotherapy given into the vein (systemic) or melphalan chemotherapy given into the artery that feeds the eye (intra-arterial). However, either treatment alone may not be able to control advanced retinoblastoma. Giving a combination of standard chemotherapy and melphalan or melphalan alone in different interval schedules may be a better treatment for advanced intra-ocular retinoblastoma.
    Location: UCSF Medical Center-Mount Zion, San Francisco, California

  • Anti-GD2 Monoclonal Antibody Hu14.18K322A and Combination Chemotherapy before Autologous Stem Cell Transplant and Radiation Therapy in Treating Younger Patients with Previously Untreated High-Risk Neuroblastoma

    This phase II trial studies how well anti-GD2 monoclonal antibody hu14.18K322A and combination chemotherapy before autologous stem cell transplant and radiation therapy works in treating younger patients with previously untreated high-risk neuroblastoma. Giving chemotherapy before a donor bone marrow transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. Also, monoclonal antibodies, such as anti-GD2 monoclonal antibody hu14.18K322A, can find cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
    Location: St. Jude Children's Research Hospital, Memphis, Tennessee

  • Combination Chemotherapy in Treating Patients with Newly Diagnosed, Previously Untreated Intraocular Retinoblastoma

    This clinical trial studies combination chemotherapy in treating patients with newly diagnosed, previously untreated intraocular retinoblastoma. Drugs used in chemotherapy, such as vincristine sulfate, carboplatin, topotecan hydrochloride, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. In this trial, the first two courses of chemotherapy will be given directly to the eye, and followed by additional chemotherapy. Giving the first two courses of chemotherapy directly into the eye may improve the tumor's response to treatment.
    Location: St. Jude Children's Research Hospital, Memphis, Tennessee


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