Clinical Trials Using Cabazitaxel

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Cabazitaxel. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-7 of 7
  • Abiraterone Acetate with or without Cabazitaxel in Treating Patients with Metastatic Castration-Resistant Prostate Cancer

    This randomized phase II trial studies how well abiraterone acetate with cabazitaxel works and compares to abiraterone acetate alone in treating patients with prostate cancer that has spread to other places in the body (metastatic) and is resistant to surgical removal (castration-resistant). Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as abiraterone acetate, may lessen the amount of androgens made by the body. Drugs used in chemotherapy, such as cabazitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether abiraterone acetate is more effective with or without cabazitaxel in treating prostate cancer.
    Location: 5 locations

  • Rapid Cycle Combination Therapy in Treating Patients with Metastatic Castrate-Resistant Prostate Cancer

    This phase II trial studies how well rapid cycle combination therapy works in treating patients with prostate cancer that has not responded to surgery or hormone therapy and has spread to other places in the body. Androgen can cause the growth of tumor cells. Antihormone therapy, such as abiraterone acetate and enzalutamide, may lessen the amount of androgen made by the body. Drugs used in the chemotherapy, such as radium Ra 223 dichloride, cabazitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Switching between different combinations of androgen deprivation therapy and chemotherapy after a short time may prevent drug resistance and help achieve better long-term control of prostate cancer.
    Location: 3 locations

  • Enzalutamide and Cabazitaxel in Treating Patients with Metastatic, Castration-Resistant Prostate Cancer

    This phase I / II trial studies the side effects and best dose of cabazitaxel when given together with enzalutamide in treating patients with prostate cancer that has spread to other places in the body (metastatic) and has not responded to treatment with hormones (hormone-resistant). Drugs used in chemotherapy, such as cabazitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Androgen can cause the growth of prostate cancer cells. Hormone therapy using enzalutamide may fight prostate cancer by blocking the use of androgen by the tumor cells. Giving cabazitaxel together with enzalutamide may work better in treating metastatic, hormone-resistant prostate cancer.
    Location: 3 locations

  • Docetaxel or Cabazitaxel with Clarithromycin in Treating Patients with Metastatic Castration-Resistant Prostate Cancer

    This phase Ib trial studies the side effects and best dose of docetaxel or cabazitaxel when given together with clarithromycin in treating patients with castration-resistant prostate cancer that has spread to other places in the body. Drugs used in chemotherapy, such as docetaxel and cabazitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Clarithromycin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving docetaxel or cabazitaxel with clarithromycin may work better in treating patients with castration-resistant prostate cancer.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Abiraterone Acetate, Prednisone, and Apalutamide with or without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients with Metastatic Castration-Resistant Prostate Cancer

    This randomized phase II trial studies the side effects and how well abiraterone acetate, prednisone, and apalutamide work with or without ipilimumab or cabazitaxel and carboplatin in treating patients with castration-resistant prostate cancer that has spread to other places in the body. Androgens can cause the growth of prostate cancer cells. Drugs, such as abiraterone acetate and apalutamide may lessen the amount of androgens made by the body. Monoclonal antibodies, such as ipilimumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as prednisone, cabazitaxel, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving abiraterone acetate, prednisone, and apalutamide with or without ipilimumab or cabazitaxel and carboplatin may be a better way to treat patients with castration-resistant prostate cancer that has spread to other places in the body.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Cabazitaxel, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients with BCG Solution-Refractory Non-muscle Invasive Urothelial Carcinoma of the Bladder

    This phase I trial studies the side effects and best dose of cabazitaxel and cisplatin when given together with gemcitabine hydrochloride in treating patients with non-muscle invasive urothelial carcinoma of the bladder that has not responded to Bacillus Calmette-Guerin (BCG) solution (refractory). Drugs used in chemotherapy, such as cabazitaxel, gemcitabine hydrochloride, and cisplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: Columbia University / Herbert Irving Cancer Center, New York, New York

  • Cabazitaxel and Prednisone in Treating Patients with Metastatic Hormone-Resistant Prostate Cancer

    This phase II trial studies how well cabazitaxel and prednisone work in treating patients with hormone-resistant prostate cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as cabazitaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: University of California Davis Comprehensive Cancer Center, Sacramento, California