Clinical Trials Using Aminolevulinic Acid

Clinical trials are research studies that involve people. The clinical trials on this list are studying Aminolevulinic Acid. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • A Contrast Agent, Fluorescein, for the Identification of Tumor Tissue during Surgery in Patients with Low or High Grade Glioma

    This phase II trial studies how well a contrast agent called fluorescein works compared to aminolevulinic acid (ALA) in identifying tumor tissue during surgery in patients with low or high grade glioma. Fluorescein is a contrast agent which glows a yellowish-green color and may help surgeons identify the tumor. ALA is produced naturally in the body and helps to make the hemoglobin in blood. As part of this process, ALA is turned into another molecule called protoporphyrin IX (PpIX) which glows a reddish-pink color. More PpIX can be produced by tumor cells than is produced by the normal cells in the brain if extra ALA is given a few hours before surgery. The purpose of this trial is to learn whether fluorescein may help surgeons identify the brain tumor during surgery and to compare fluorescein to ALA in identifying brain tumors during surgery.
    Location: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire