Clinical Trials Using Hydroxychloroquine

Clinical trials are research studies that involve people. The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-7 of 7
  • Dabrafenib, Trametinib and Hydroxychloroquine in Treating Patients with Stage IV Metastatic Melanoma

    This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with dabrafenib and trametinib and to see how well they work in treating patients with stage IV melanoma that has spread to other places in the body. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sometimes when dabrafenib and trametinib are given, the tumor cells activate a stress response called autophagy. Autophagy provides resistance to dabrafenib and trametinib treatment over time making them less effective. Giving hydroxychloroquine with dabrafenib and trametinib may reduce drug resistance and allow more tumor cells to be killed.
    Location: 3 locations

  • A Phase I / II / Pharmacodynamic Study of Hydroxychloroquine in Combination With Gemcitabine / Abraxane to Inhibit Autophagy in Pancreatic Cancer

    In this Phase I / II clinical trial, the investigators seek to pilot the addition of Hydroxychloroquine (HCQ) to a commonly-used front-line therapy of pancreatic cancer, gemcitabine / nab-paclitaxel. The investigators plan a run-in to define tolerable doses, and will explore doses of 800 and 1200 mg / day in successive cohorts of 6 patients. The investigators will assess toxicity continuously, and determine the dose for the Phase II trial based on standard toxicity criteria.
    Location: 2 locations

  • Trametinib and Hydroxychloroquine in Treating Patients with Locally Advanced or Metastatic and Unresectable Pancreatic Cancer

    This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer.
    Location: Huntsman Cancer Institute / University of Utah, Salt Lake City, Utah

  • Hydroxychloroquine, Palbociclib, and Letrozole before Surgery in Treating Participants with Estrogen Receptor Positive, HER2 Negative Breast Cancer

    This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with palbociclib and letrozole before surgery in treating participants with estrogen receptor positive, HER2 negative breast cancer. Hydroxychloroquine is a substance that decreases immune responses in the body. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Drugs, such as letrozole, may lessen the amount of estrogen made by the body. Giving hydroxychloroquine, palbociclib, and letrozole before surgery may work better than palbociclib and letrozole in treating participants with breast cancer.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants with Recurrent or Refractory Osteosarcoma

    This phase I / II trial studies the side effects and best dose of hydroxychloroquine and how well it works when given together with gemcitabine and docetaxel in treating participants with osteosarcoma that has come back or does not respond to treatment. Drugs used in chemotherapy, such as gemcitabine, docetaxel, and hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Gedatolisib, Hydroxychloroquine or the Combination for Prevention of Recurrent Breast Cancer (“GLACIER”)

    This phase I / II trial studies the side effects of hydroxychloroquine with or without gedatolisib and to see how well they work in preventing cancer from coming back in patients with stage I-III breast cancer. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Gedatolisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving hydroxychloroquine alone or in combination with gedatolisib may reduce or eliminate breast cancer cells that have spread to the bone marrow in patients with stage I-III breast cancer.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • CPI-613 and Hydroxychloroquine in Treating Patients with Recurrent High Risk Myelodysplastic Syndrome

    This phase I / II trial studies the side effects and best dose of hydroxychloroquine and how well CPI-613 and hydroxychloroquine work in treating patients with high risk myelodysplastic syndrome that has come back after hypomethylating therapy. CPI-613 is thought to kill cancer cells by turning off their mitochondria. Mitochondria are used by cells to produce energy and are the building blocks needed to make more cells. By shutting off these mitochondria, CPI-613 deprives the cells of energy and other supplies that they need to survive and grow in your body. Hydroxychloroquine is an antimalarial drug. Hydroxychloroquine may make CPI-613 more effective in treating patients with myelodysplastic syndrome.
    Location: 2 locations