Clinical Trials Using Idelalisib
Clinical trials are research studies that involve people. The clinical trials on this list are studying Idelalisib. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Idelalisib in Treating Participants with Indolent or Transformed Indolent Non-Hodgkin Lymphoma after Autologous Stem Cell Transplant
This phase II trial studies the side effects of idelalisib and how well it works in treating participants with indolent or transformed indolent non-Hodgkin lymphoma after undergoing autologous stem cell transplant. Idelalisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: 2 locations
Pembrolizumab Alone or with Idelalisib or Ibrutinib in Treating Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas
This phase II trial studies how well pembrolizumab alone or with idelalisib or ibrutinib works in treating patients with chronic lymphocytic leukemia or other low-grade B-cell non-Hodgkin lymphomas that have returned after a period of improvement or have not responded to treatment. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Idelalisib and ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab alone or with idelalisib or ibrutinib may be an effective treatment in patients with chronic lymphocytic leukemia or other low-grade B-cell non-Hodgkin lymphomas.
Location: 2 locations
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
This phase Ib trial determines if samples from a patient’s cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has. This study is also being done to understand why cancer drugs can stop working and how different cancers in different people respond to different types of therapy.
Location: OHSU Knight Cancer Institute, Portland, Oregon
Dose Optimization Study of Idelalisib in Follicular Lymphoma
The primary objective of this study is to establish a safe and effective dosing regimen of idelalisib in participants with relapsed or refractory follicular lymphoma (FL) who have no other therapeutic options.
Location: See Clinical Trials.gov
Rituximab, Idelalisib, and Venetoclax in Treating Participants with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This phase I trial studies the best dose and side effects of idelalisib and venetoclax when given together with rituximab for the treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Idelalisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as venetoclax, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving rituximab, idelalisib and venetoclax may work better at treating relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
Location: Virginia Commonwealth University / Massey Cancer Center, Richmond, Virginia