Clinical Trials Using Lenvatinib Mesylate

Clinical trials are research studies that involve people. The clinical trials on this list are studying Lenvatinib Mesylate. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Lenvatinib and Pembrolizumab for the Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma or Other Salivary Gland Cancers

    This phase II trial studies how well lenvatinib and pembrolizumab work in treating patients with adenoid cystic carcinoma or other salivary gland cancers that have come back (recurrent) or have spread to other places in the body (metastatic). Lenvatinib works by blocking receptor tyrosine kinases, proteins that help cells grow and develop blood vessels. Blocking these proteins may slow the growth of cancer cells and cut off the blood supply that feeds them. Pembrolizumab blocks a protein, PD-1, that acts as a “brake” on the immune system. Blocking this protein is like releasing the brakes; it frees the immune system to target and kill cancer cells. Giving lenvatinib and pembrolizumab may work better in slowing and stopping the growth of adenoid cystic carcinoma or other salivary gland cancers compared to lenvatinib or pembrolizumab alone.
    Location: 7 locations

  • Lenvatinib Mesylate and Cetuximab in Treating Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma or Cutaneous Squamous Cell Carcinoma

    This phase I / Ib trial studies the best dose and side effects of lenvatinib mesylate and cetuximab in treating patients with head and neck squamous cell carcinoma or cutaneous squamous cell carcinoma that has come back (recurrent) or spread to other places in the body (metastatic). Lenvatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, may interfere with the ability of tumor cells to grow and spread. Giving lenvatinib mesylate and cetuximab may work better in treating patients with head and neck squamous cell carcinoma or cutaneous squamous cell carcinoma.
    Location: 7 locations

  • Lenvatinib and Pembrolizumab before Surgery for the Treatment of Locally Advanced Non-Metastatic Kidney Cancer

    This phase II trial studies how well lenvatinib and pembrolizumab before surgery work in treating patients with kidney cancer that has spread from its original site of growth to nearby tissues or lymph nodes (locally advanced) but has not spread to other places in the body (non-metastatic). Lenvatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving lenvatinib and pembrolizumab before surgery may kill more tumor cells.
    Location: Emory University Hospital / Winship Cancer Institute, Atlanta, Georgia