Clinical Trials Using Liposomal Bupivacaine

Clinical trials are research studies that involve people. The clinical trials on this list are studying Liposomal Bupivacaine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-5 of 5
  • Four Quadrants Transverse Abdominus Plane Block with Bupivacaine Hydrochloride and Liposomal Bupivacaine in Treating Participants Undergoing Cytoreductive Surgery

    This phase III trial studies how well four quadrants transverse abdominus plane block with bupivacaine hydrochloride and liposomal bupivacaine work in treating participants undergoing specialized abdominal surgery for cancer. Four quadrants transverse abdominus plane block is a procedure that delivers anesthesia such as bupivacaine hydrochloride and liposomal bupivacaine to help relieve pain after surgery. Four quadrants transverse abdominus plane block may work better in relieving pain after cytoreductive surgery.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Liposomal Bupivacaine with or without Hydromorphone for the Improvement of Pain Control after Laparotomy in Patients with Gynecological Malignancies

    This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy. Liposomal bupivacaine is routinely infiltrated into the skin surrounding the abdominal incision, and is effective in providing good relief of incisional pain. Hydromorphone is also a type of pain medication that may provide better management of deep abdominal pain. It is not yet known if giving liposomal bupivacaine with or without hydromorphone will work better in improving pain in patients with gynecological malignancies during the first 24 hours after surgery.
    Location: Mayo Clinic in Rochester, Rochester, Minnesota

  • Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions after Surgery in Retroperitoneal Sarcoma Patients ("RESQU-SARC" Trial)

    This phase II trial studies how well a repeat or single liposomal bupivacaine injection (quadratus lumborum block) works in reducing opioid prescriptions after surgery in patients with retroperitoneal sarcoma. Liposomal bupivacaine is a numbing medication. Giving a second injection block may decrease dependency on opioid medications for pain relief after surgery and prevent long-term use and addiction.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Thoracic Epidural Analgesia versus Liposomal Bupivacaine Surgical Site Infiltration for the Treatment of Pain in Patients Undergoing Gynecologic Surgery

    This phase III trial compares thoracic epidural analgesia (TEA) to surgical site infiltration with liposomal bupivacaine in treating pain in patients undergoing gynecologic surgery. Using an epidural (an infusion of pain medication [bupivacaine] into the spinal column) after surgery has been shown to help control pain and decrease the amount of pain medication needed by mouth. Injection of the surgical incision with the long acting anesthetic (pain medication) called liposomal bupivacaine has also been shown to be beneficial for pain control and to decrease the amount of pain medication needed by mouth. Surgical site infiltration with liposomal bupivacaine may work the same as TEA in controlling pain after surgery.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery

    This phase III trial studies how well thoracic epidural analgesia or four-quadrant transversus abdominus plane block works in reducing pain in patients undergoing liver surgery. It is not yet known whether thoracic epidural analgesia or four-quadrant transversus abdominus plane block may help people to recover more completely and more quickly after surgery.
    Location: M D Anderson Cancer Center, Houston, Texas