Clinical Trials Using Metformin Hydrochloride
Clinical trials are research studies that involve people. The clinical trials on this list are studying Metformin Hydrochloride. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success.
Location: 20 locations
Chemotherapy with or without Metformin Hydrochloride in Treating Patients with HER2 Positive Breast Cancer That Can Be Removed by Surgery
This randomized phase II trial studies how well chemotherapy with or without metformin hydrochloride work in treating patients with HER2 positive breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, pertuzumab, and pegfilgrastim, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may prevent or lower risk of breast cancer and decrease cancer cells, lower risk of cancer spreading. It is not yet known whether giving metformin hydrochloride with chemotherapy will work better in treating patients with breast cancer.
Location: 6 locations
Metformin Hydrochloride, Cisplatin and External Beam Radiation Therapy in Treating Participants with Stage III-IV Head and Neck Squamous Cell Cancer
This phase I / II trial studies the side effects and best dose of metformin hydrochloride when given together with cisplatin and external beam radiation therapy in treating participants with stage III-IV head and neck squamous cell cancer. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External beam radiation therapy uses high-energy beams to kill tumor cells and shrink tumors. Giving metformin hydrochloride, cisplatin and external beam radiation therapy may work better at treating head and neck squamous cell cancer.
Location: 3 locations
Metformin Hydrochloride and Levonorgestrel-Releasing Intrauterine System in Treating Patients with Atypical Endometrial Hyperplasia or Endometrial Cancer
This early phase I trial studies how well metformin hydrochloride works when added to levonorgestrel-releasing intrauterine system in treating patients with atypical endometrial hyperplasia or endometrial cancer who cannot undergo surgery. Metformin hydrochloride is a widely-used type II diabetes drug that may also stop cancer cells from dividing. Estrogen may cause cancer. Levonorgestrel-releasing intrauterine system is a device placed in the uterus that reduces the level of estrogen in the body. Giving metformin hydrochloride in addition to treatment with levonorgestrel-releasing intrauterine system may be an effective alternative for patients with atypical endometrial hyperplasia or endometrial cancer who cannot undergo surgery.
Location: 3 locations
Metformin and Digital Lifestyle Intervention (Noom) for the Prevention of Diabetes in Childhood Cancer Survivors with Prediabetes
This phase II trial studies the effect of metformin and a smartphone application (app)-based lifestyle program, called Noom in preventing diabetes in childhood cancer survivors with blood sugar levels that are higher than normal but not yet high enough to be diabetes (prediabetes). Metformin is a type of antidiabetic drug that decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body's use of the glucose. The Noom program includes dietary change and at least 150 minutes / week moderate intensity physical activity (brisk walking, biking, swimming, etc.) using a digital, app-based platform that includes a lifestyle coach who helps facilitate a core-curriculum focused on diet, exercise and behavioral strategies for goal setting and self-monitoring. Giving metformin and the Noom program may help improve blood sugar levels and reduce the risk of developing diabetes.
Location: Saint Jude Children's Research Hospital, Memphis, Tennessee
Metformin, Nelfinavir, and Bortezomib in Treating Patients with Relapsed and / or Refractory Multiple Myeloma
This phase I trial studies the side effects and best dose of metformin and nelfinavir in combination with bortezomib in treating patients with multiple myeloma that has come back or does not respond to treatment. Metformin may stop the growth of tumor cells by disrupting the energy source within multiple myeloma cells. Nelfinavir and bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving metformin, nelfinavir, and bortezomib may work better in treating patients with multiple myeloma.
Location: Mayo Clinic in Rochester, Rochester, Minnesota
Metformin Hydrochloride and Combination Chemotherapy in Treating Patients with Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This partially randomized phase II trial studies how well metformin hydrochloride and combination chemotherapy work in treating patients with stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor cells more sensitive to the drugs. Studying samples of blood and tissue in the laboratory from patients receiving metformin hydrochloride may help doctors learn more about the effects of metformin hydrochloride on cells. It may also help doctors understand how well patients respond to treatment. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells.
Location: 12 locations
Metformin Hydrochloride in Treating Patients with Relapsed Chronic Lymphocytic Leukemia or Untreated Chronic Lymphocytic Leukemia with Genomic Deletion 11q
This pilot phase II trial studies how well metformin hydrochloride works in treating patients with chronic lymphocytic leukemia that has come back or untreated chronic lymphocytic leukemia with genomic deletion 11q. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Location: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Metformin Hydrochloride in Mitigating Side Effects of Radioactive Iodine Treatment in Patients with Differentiated Thyroid Cancer
This phase II pilot trial studies how will metformin hydrochloride works in mitigating the side effects of radioactive iodine treatment in patients with differentiated thyroid cancer. Metformin hydrochloride may reduce the metabolic activity of cancer cell and of surrounding supportive tissues.
Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Metformin Hydrochloride in Preventing Breast Cancer in Patients with Atypical Hyperplasia or In Situ Breast Cancer
This phase III trial studies how well metformin hydrochloride works compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of metformin hydrochloride may prevent breast cancer.
Location: 14 locations
Effects of Metformin Hydrochloride in Participants with Malignant Solid Tumors
This early phase I trial studies the effects of metformin hydrochloride in participants with malignant solid tumors. Metformin, a drug typically used for the treatment of diabetes, may help to reduce the growth of cancerous tumor cells in participants with malignant solid tumors.
Location: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire