Clinical Trials Using Mifepristone
Clinical trials are research studies that involve people. The clinical trials on this list are studying Mifepristone. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Nab-Paclitaxel with or without Mifepristone in Treating Patients with Glucocorticoid Receptor Positive Stage IV or Stage III Triple-Negative Breast Cancer That Cannot Be Removed by Surgery
This randomized phase II trial studies how well paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel) with or without mifepristone works in treating glucocorticoid receptor positive stage IV or stage III triple-negative breast cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Progesterone and glucocorticoid can cause the growth of tumor cells. Hormone therapy using mifepristone may fight breast cancer by lowering the amount of progesterone and glucocorticoid the body makes or by blocking the use of progesterone and glucocorticoid by the tumor cells. It is not yet known whether nab-paclitaxel is more effective with or without mifepristone in treating patients with breast cancer.
Location: 4 locations
Pembrolizumab and Mifepristone in Treating Patients with Metastatic or Locally Advanced and Unresectable HER2-Negative Breast Cancer
This phase II trial studies how well pembrolizumab and mifepristone works in treating patients with HER2-negative breast cancer that has spread to other places in the body, or to nearby tissues or lymph nodes and cannot be removed by surgery. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Hormone therapy using mifepristone may fight breast cancer by lowering the amount of progesterone and glucocorticoid the body makes. Giving pembrolizumab and mifepristone may work better in treating patients with HER2-negative breast cancer.
Location: 2 locations