Clinical Trials Using Pomalidomide
Clinical trials are research studies that involve people. The clinical trials on this list are studying Pomalidomide. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Vactosertib and Pomalidomide in Treating Participants with Relapsed or Relapsed and Refractory Multiple Myeloma
This phase I trial studies the side effects and best dose of vactosertib when given together with pomalidomide in treating participants with multiple myeloma that has come back after treatment or has come back and does not respond to treatment. Vactosertib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Pomalidomide may stop the growth of cancer cells by blocking the growth of new blood vessels necessary for tumor growth. Giving vactosertib and pomalidomide may work better in treating participants relapsed or relapsed and refractory multiple myeloma.
Location: Case Comprehensive Cancer Center, Cleveland, Ohio
HDAC Inhibitor AR-42 and Pomalidomide in Treating Patients with Relapsed Multiple Myeloma
This phase Ib trial studies the side effects and best dose of histone deacetylase (HDAC) inhibitor AR-42 (AR-42) when given together with pomalidomide in treating patients with multiple myeloma that has returned after a period of improvement. HDAC inhibitor AR-42 may work to stop cancer growth by blocking an enzyme needed for cell growth. Pomalidomide is a drug used in chemotherapy that works to stop the growth of cancer cells by causing them to die. Giving HDAC inhibitor AR-42 together with pomalidomide may cause patients to respond better to treatment.
Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio