Clinical Trials Using Recombinant Human Papillomavirus Nonavalent Vaccine

Clinical trials are research studies that involve people. The clinical trials on this list are studying Recombinant Human Papillomavirus Nonavalent Vaccine. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-5 of 5
  • HPV Vaccine Therapy in Interrupting Progression in Patients with High-Grade Vulvar or Anal Lesions

    This randomized phase IV trial studies how well human papillomavirus (HPV) vaccine therapy works in interrupting progression in patients with high-grade vulvar or anal lesions. Vaccines made from HPV peptides or antigens may help the body build an effective immune response to kill tumor cells and decrease the chance of vulvar or anal lesions to progress or come back.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Imiquimod with or without 9-Valent HPV Vaccine in Treating Patients with High-Grade Pre-neoplastic Cervical Lesions

    This phase II trial studies how well imiquimod with or without 9-valent human papillomavirus (HPV) vaccine work in treating patients with high-grade pre-neoplastic cervical lesions. Imiquimod may help to improve patients' immune system. Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Giving booster vaccinations may make a stronger immune response and prevent or delay the recurrence of cancer. It is not yet known whether giving imiquimod with or without 9-valent HPV vaccine may work better in treating patients with cervical lesions.
    Location: Yale University, New Haven, Connecticut

  • Preventive Human Papilomavirus (HPV) Vaccine Trial in Kidney Transplant Recipients

    This trial studies whether the nonavalent human papillomavirus vaccine given to adult women prior to kidney transplantation can help the body build and maintain an effective immune response during the post-transplant period when they receive immunosuppressive drugs to prevent transplant rejection. This study will help inform our scientific understanding about vaccine-induced immune responses among immunosuppressed individuals.
    Location: 5 locations

  • HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients with HIV and HPV

    This randomized phase III trial studies how well human papillomavirus (HPV) vaccine therapy works in reducing high-grade cervical lesions in patients with human immunodeficiency virus (HIV) and HPV. Vaccines made from HPV peptides or antigens may help the body build an effective immune response to kill the HPV virus and prevent cervical lesions from developing or coming back after being removed.
    Location: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

  • Gardasil 9 Vaccine in Preventing HPV Infection in Patients with Hematologic Malignancies Undergoing Donor Stem Cell Transplant

    This phase IV trial studies how well Gardasil 9 vaccine works in preventing human papillomavirus (HPV) infection in patients with hematologic malignancies who are undergoing donor stem cell transplant. Vaccines, such as Gardasil 9, may help the body build an effective immune response to kill cancer cells.
    Location: M D Anderson Cancer Center, Houston, Texas