Clinical Trials Using Simvastatin

Clinical trials are research studies that involve people. The clinical trials on this list are studying Simvastatin. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Simvastatin in Treating Patients with Stage I-II Breast Cancer

    This pilot phase II trial studies how well simvastatin works in treating patients with stage I-II breast cancer. Simvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and reduce the aggressiveness of breast cancer cells.
    Location: 3 locations

  • Simvastatin, Topotecan Hydrochloride, and Cyclophosphamide in Treating Younger Patients with Relapsed and / or Refractory Solid and CNS Tumors

    This phase I trial studies the side effects and best dose of simvastatin when given together with topotecan hydrochloride and cyclophosphamide in treating younger patients with solid and central nervous system (CNS) tumors that have returned (relapsed) and / or that do not respond to treatment (refractory). Simvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan hydrochloride and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving simvastatin together with topotecan hydrochloride and cyclophosphamide may be a better treatment for solid and CNS tumors.
    Location: Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia

  • Simvastatin in Preventing Liver Cancer in Patients with Liver Cirrhosis

    This randomized phase II trial studies how well simvastatin works in preventing liver cancer in patients with liver cirrhosis. Simvastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
    Location: 4 locations