Clinical Trials Using Sonidegib

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Clinical trials are research studies that involve people. The clinical trials on this list are studying Sonidegib. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Ribociclib, Gemcitabine Hydrochloride, Trametinib and Sonidegib in Treating Participants with Refractory or Recurrent Brain Cancers

    This phase I trial studies the best dose and side effects of ribociclib, gemcitabine hydrochloride, trametinib and sonidegib in treating children and young adults with brain cancers that have come back or do not respond to treatment. Ribociclib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride and sonidegib work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ribociclib, gemcitabine hydrochloride, trametinib and sonidegib may work better at treating brain cancers.
    Location: St. Jude Children's Research Hospital, Memphis, Tennessee

  • Erismodegib and Paclitaxel in Treating Patients with Recurrent Ovarian Cancer

    This phase IB / II trial studies the side effects and how well erismodegib when given together with paclitaxel works in treating patients with ovarian cancer that has come back. Drugs used in chemotherapy, such as erismodegib and paclitaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

  • Sonidegib in Treating Patients with Advanced or Metastatic Liver Cancer That Cannot Be Removed by Surgery or Child-Pugh A / B7 Cirrhosis

    This phase I trial studies the side effects and best dose of sonidegib in treating patients with liver cancer that has spread to other parts of the body and cannot be removed by surgery or Child-Pugh A / B7 cirrhosis. Sonidegib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: University of California San Diego, San Diego, California

  • Sonidegib and Lenalidomide after Stem Cell Transplant in Treating Patients with Multiple Myeloma

    This phase II trial studies how well sonidegib and lenalidomide after stem cell transplant works in treating patients with multiple myeloma. Sonidegib and lenalidomide may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and may delay multiple myeloma from coming back after a stem cell transplant.
    Location: Mayo Clinic, Rochester, Minnesota