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Clinical Trials Using Sotorasib

Review the clinical trials studying sotorasib on this list and use the filters to refine the results by age and location. Some clinical trials are held at NCI-Designated Cancer Centers and may be supported by other organizations.

You can find more information about the types and phases of clinical trials and what to expect or use our Steps to Find a Clinical Trial.

Trials 1-15 of 15

Testing the use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)
Status: Active
Location: 174 locations
A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Status: Active
Location: 25 locations
Sotorasib as First-line Treatment for Patients with KRAS G12C Mutant Metastatic or Recurrent Non-Small Cell Lung Cancer
Status: Active
Location: 7 locations
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Status: Active
Location: 6 locations
AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Status: Active
Location: 5 locations
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Status: Active
Location: 4 locations
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Status: Active
Location: 4 locations
Sotorasib, Cisplatin or Carboplatin, and Pemetrexed for the Treatment of Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer with a KRAS p.G12C Mutation
Status: Active
Location: 2 locations
Carfilzomib in Combination with Sotorasib for the Treatment of Patients with KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer
Status: Active
Location: 2 locations
Sotorasib in Combination with Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer with a KRAS G12C Mutation
Status: Active
Location: See ClinicalTrials.gov
A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors
Status: Active
Location: Moffitt Cancer Center, Tampa, Florida
A Study of NB004 As Monotherapy or Combination Therapy in Patients with Advanced Solid Tumors
Status: Active
Location: See ClinicalTrials.gov
Sotorasib in Combination with Chemotherapy for Second Line Treatment of KRAS G12C Mutated Metastatic or Unresectable Pancreatic Cancer
Status: Approved
Location: Northwestern University, Chicago, Illinois
Biomarker-Driven Therapy and Immunotherapy in Screening Participants with Recurrent or Stage IV Non-Small Cell Lung Cancer (The Expanded Lung-MAP Screening Trial)
Status: Active
Location: 1103 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients with Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Status: Active
Location: 442 locations