Clinical Trials Using Vincristine
Clinical trials are research studies that involve people. The clinical trials on this list are studying Vincristine. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667 / KEYNOTE-667)
This study will examine the safety and efficacy of pembrolizumab (MK-3475) in combination with chemotherapy in children and young adults with newly diagnosed classical Hodgkin Lymphoma (cHL) who are slow early responders (SERs) to frontline chemotherapy.
Location: Wayne State University / Karmanos Cancer Institute, Detroit, Michigan
Roflumilast and Standard Chemoimmunotherapy in Treating Participants with Stage II-IV High-Risk Diffuse Large B-Cell Lymphoma
This phase 1 trial studies the side effects of roflumilast and standard chemoimmunotherapy (R-CHOP: cyclophosphamide, vincristine, doxorubicin, rituximab, prednisone) in treating participants with stage II-IV high-risk diffuse large B-cell lymphoma. Roflumilast may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as R-CHOP, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving roflumilast and standard chemoimmunotherapy may work better in treating participants with stage II-IV high-risk diffuse large B-cell lymphoma.
Location: Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio, Texas