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Retinoblastoma Treatment (PDQ®)

  • Last Modified: 01/28/2014

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Treatment Options for Retinoblastoma

Intraocular Retinoblastoma
Extraocular Retinoblastoma
Recurrent Retinoblastoma



Intraocular Retinoblastoma

If the tumor is large and it is expected that the eye cannot be saved, treatment may include the following:

If it is expected that the eye can be saved, treatment may include the following:

When retinoblastoma is in both eyes, the treatment for each eye may be different depending on the size of the tumor and whether it is expected that the eye can be saved.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with intraocular retinoblastoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Extraocular Retinoblastoma

Treatment for extraocular retinoblastoma that has spread to the area around the eye may include the following:

Treatment for extraocular retinoblastoma that has spread to the brain may include the following:

It is not clear whether extraocular retinoblastoma that has spread to the brain responds to chemotherapy or radiation therapy.

For trilateral retinoblastoma, treatment may include the following:

  • Chemotherapy followed by high-dose chemotherapy with stem cell rescue.

For retinoblastoma that has spread to other parts of the body, treatment may include the following:

  • Chemotherapy followed by high-dose chemotherapy with stem cell rescue.
  • A clinical trial of chemotherapy followed by high-dose chemotherapy with stem cell rescue and radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with extraocular retinoblastoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Recurrent Retinoblastoma

Treatment of recurrent retinoblastoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent retinoblastoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.