Prevention Clinical Trials for Prostate Cancer

Clinical trials are research studies that involve people. The clinical trials on this list are for prostate cancer prevention. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-8 of 8
  • A Study of Hydroxychloroquine versus Placebo to Prevent COVID-19 Infection in Patients Receiving Radiation Therapy

    This phase II trial studies how well hydroxychloroquine works in preventing infection with the COVID-19 virus in patients receiving radiation therapy. Hydroxychloroquine has been approved for the prevention and treatment of malaria, and the treatment of lupus and rheumatoid arthritis. Receiving radiation therapy may increase the risk of infection with the COVID-19 virus because the patients are in frequent and close contact with healthcare workers and with other patients who may have become infected. Patients receiving treatment for cancer may also have weakened immune system. Giving hydroxychloroquine may help prevent infection with SARS-CoV-2 in patients who are receiving radiation therapy for their cancer.
    Location: 7 locations

  • Aerobic Exercise in Changing Biomarkers in Patients with Solid Tumors or Clonal Hematopoiesis

    This trial studies the effect of aerobic exercise in changing biomarkers in patients with solid tumors or clonal hematopoiesis, a condition in which some of the patients' blood cells have a different genetic pattern than the rest of the blood cells. Aerobic exercise stimulates and strengthens the heart and lungs, and improves the body’s use of oxygen. This may help prevent or slow the growth of tumors by changing the biomarkers (signs of disease) found in the blood or by preventing recurrence of certain cancers.
    Location: 7 locations

  • Diet and Exercise Interventions for Improving Outcomes in Men with Prostate Cancer

    This trial studies how well diet and exercise interventions work in improving biological, clinical, and quality of life outcomes in men with prostate cancer undergoing radical prostatectomy. Following diet and exercise interventions may prevent the prostate cancer from coming back or progressing.
    Location: 4 locations

  • Web-Based Diet and Exercise Intervention for the Reduction of Obesity and Improvement of Health in Cancer Survivors and Their Partners

    This clinical trial studies the effect of a web-based diet and exercise intervention in reducing obesity and improving the health of cancer survivors and their partners. The purpose of this trial is to learn how a web-based diet and exercise intervention affects the health behaviors of cancer survivors and the people around them, as well as how it affects body weight, overall health and ability to move, quality of life, and blood markers of successful aging.
    Location: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

  • Daily, Long-Term Intermittent Fasting for the Prevention of PSA-Recurrence in Patients with Localized Prostate Cancer after Radical Prostatectomy

    This early phase I trial studies the feasibility of a daily, long-term intermittent fasting routine in preventing or delaying a rise in prostate specific antigen (PSA) levels in patients with prostate cancer that has not spread to other parts of the body (localized) and who have undergone radical prostatectomy. PSA is a protein produced by both normal and cancer cells. Following a daily fasting routine after treatment for prostate cancer may lower the risk of patients' PSA level rising above 0.4 ng / mL, which is also called PSA-recurrence. A PSA-recurrence can sometimes mean that the disease has returned and / or progressed.
    Location: Mayo Clinic in Rochester, Rochester, Minnesota

  • Soy Bread Diet in Improving Immune Function in Participants with Prostate Cancer

    This phase II trial studies the effects of a soy bread diet in improving immune function in participants who are undergoing surgery for prostate cancer. Components found in soy foods may influence the immune system in a way that may be beneficial for prostate cancer prevention and survivorship.
    Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

  • Systematic Light Exposure for the Prevention of Fatigue in Prostate Cancer Patients

    This trial investigates systematic light exposure in preventing fatigue in prostate cancer patients. Prostate cancer patients receiving radiation therapy may feel tired or worn out, find it harder to concentrate or remember things, or may just not like feel like themselves. Systematic light exposure (with a light box) may prevent side-effects experienced during radiation treatment. This trial may help researchers evaluate whether patients receiving radiation therapy for prostate cancer who are regularly exposed to light from a light box during their treatment will experience reduction of symptoms they may experience during their treatment.
    Location: Northwestern University, Chicago, Illinois

  • To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

    This phase II trial studies whether green tea catechins can prevent progression of prostate cancer from a low risk stage to higher risk stages in men who are on active surveillance. Green tea catechins may stabilize prostate cancer and lower the chance of prostate growth.
    Location: Location information is not yet available.