Clinical Trials Using Liposomal Irinotecan
Clinical trials are research studies that involve people. The clinical trials on this list are studying Liposomal Irinotecan. All trials on the list are supported by NCI.
NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.
Liposomal Irinotecan and Veliparib in Treating Patients with Solid Tumors
This phase I trial studies the side effects and best dose of veliparib when given together with liposomal irinotecan in treating patients with solid tumors. Liposomal irinotecan and veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: 6 locations
Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma
This is an open-label, phase 2 comparative study to assess the safety, tolerability, and efficacy of nal-IRI in combination with other anticancer therapies, compared to nab-paclitaxel + gemcitabine, in patients with advanced pancreatic adenocarcinoma who have not received prior chemotherapy. This study will assess the following regimens: - nal-IRI + 5-FU / LV + oxaliplatin - nal-IRI + 5-FU / LV - nab-paclitaxel + gemcitabine The study will be conducted in two parts: 1. a safety run-in of the nal-IRI + 5-FU / LV + oxaliplatin regimen, and 2. a randomized, efficacy study of nal-IRI + 5-FU / LV + oxaliplatin, and nal-IRI + 5-FU / LV, versus nab-paclitaxel + gemcitabine.
Location: 5 locations
Liposomal Irinotecan in Treating Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
This phase I trial studies the side effects and best dose of liposomal irinotecan in treating children with newly diagnosed diffuse intrinsic pontine glioma. Liposomal irinotecan may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Location: UCSF Cancer Center, San Francisco, California
Liposomal Irinotecan via Convection-Enhanced Delivery and Magnetic Resonance Imaging with Gadolinium in Treating Patients with Recurrent High Grade Glioma
This phase I trial studies the side effects and best dose of liposomal irinotecan via convection-enhanced delivery when given together with magnetic resonance imaging with gadolinium in treating patients with high grade glioma that has come back. Liposomal irinotecan may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and may reduce the toxicity of irinotecan to healthy tissues while maintaining or increasing its anti-tumor potency. Convection-enhanced delivery is a method of delivering a drug directly into the brain in order to improve the distribution of the drug throughout the brain. Diagnostic procedures, such as magnetic resonance imaging with contrast agent gadolinium, may help doctors to directly monitor the distribution of liposomal irinotecan within the brain. Giving liposomal irinotecan via convection-enhanced delivery while undergoing magnetic resonance imaging with gadolinium may work better in treating patients with high grade glioma.
Location: UCSF Medical Center-Mount Zion, San Francisco, California
MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment
This is a Phase I study to understand the biodistribution of MM-398 and to determine the feasibility of using Ferumoxytol as a tumor imaging agent.
Location: 4 locations
Phase 1 Study of MM-398 Plus Cyclophosphamide in Pediatric Solid Tumors
This is a Phase 1 study of the combination of two drugs: MM-398 and Cyclophosphamide. The goal is to find the highest dose of MM-398 that can be given safely when it is used together with the chemotherapy drug Cyclophosphamide.
Location: 2 locations