Clinical Trials Using Carboplatin

Clinical trials are research studies that involve people. The clinical trials on this list are studying Carboplatin. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 201-225 of 256

  • Hyperthermic Intraperitoneal Chemotherapy in Treating Patients with Stage IIIB-IIIC Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    This phase II trial studies how well hyperthermic intraperitoneal chemotherapy works in treating patients with stage IIIB-IIIC ovarian, fallopian tube, or primary peritoneal cancer. Hyperthermic intraperitoneal chemotherapy procedures involved infusion of a heated chemotherapy drug at the time of the cytoreductive surgery. Heating cisplatin to several degrees above normal body temperature and infusing it into the area around the tumor may kill more tumor cells and be more tolerable to patients so that intravenous chemotherapy can be started within 42 hours after surgery.
    Location: University of Kansas Cancer Center, Kansas City, Kansas

  • Defactinib Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients with Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    This phase I / II trial studies the side effects of defactinib hydrochloride in combination with carboplatin and paclitaxel and how well they work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. Enzyme inhibitors, such as defactinib hydrochloride, may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving defactinib hydrochloride with carboplatin and paclitaxel may work better in treating patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer.
    Location: 2 locations

  • Nivolumab, Paclitaxel, and Carboplatin with or without Ipilimumab in Treating Patients with High Grade Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    This phase I trial studies the side effects of nivolumab, paclitaxel, and carboplatin with or without ipilimumab in treating patients with high grade stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab, paclitaxel, and carboplatin with or without ipilimumab together may work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer compared to carboplatin and paclitaxel alone.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York

  • Pembrolizumab and Carboplatin in Treating Patients with Circulating Tumor Cells Positive Metastatic Triple-Negative Breast Cancer

    The purpose of the study is to evaluate the impact on progression-free survival (PFS) with the combination carboplatin - pembrolizumab in patients with CTC (circulating tumor cells) positive, triple-negative breast cancer that has spread to other places in the body and previously treated with anthracyclines and taxanes. Previous studies have indicated that recurrent breast cancers are more resistant to chemotherapy and maybe associated with a weak immune system. This study is investigating the use of an immune therapy drug, pembrolizumab, that has the ability to restore the capacity of controlling and killing cancer cells of an important component of your immune system called T-cells. Pembrolizumab has been found effective in other types of cancer and has already been approved by FDA for those indications, but the efficacy in breast cancer is still unknown. In this study, pembrolizumab will be combined with chemotherapy to increase the cancer cell killing. There is no control or placebo treatment in this study.
    Location: Northwestern University, Chicago, Illinois

  • PTC596 in Treating Patients with Newly Diagnosed Unresectable Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Receiving Chemotherapy

    This phase Ib trial studies the side effects and best dose of PTC596 in treating patients with newly diagnosed ovarian, fallopian tube, or primary peritoneal cancer that cannot be removed by surgery who are receiving standard of care chemotherapy. PTC596 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
    Location: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

  • Paclitaxel, Carboplatin, and Galunisertib in Treating Patients with Newly Diagnosed, Persistent, or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Carcinosarcoma

    This phase Ib trial studies the side effects and how well paclitaxel, carboplatin, and galunisertib work in treating patients with uterine, ovarian, fallopian tube, or peritoneal carcinosarcoma that is newly diagnosed, does not go to remission despite treatment (persistent), or has come back (recurrent). Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Galunisertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel, carboplatin, and galunisertib may work better in treating patients with uterine, ovarian, fallopian tube, or peritoneal carcinosarcoma.
    Location: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

  • Hyperthermic Intraperitoneal Chemotherapy in Improving Quality of Life in Patients with Stage IIIC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    This phase II trial studies how well hyperthermic intraperitoneal chemotherapy works in improving quality of life in patients with stage IIIC-IV ovarian, fallopian tube, or primary peritoneal cancer. In hyperthermic intraperitoneal chemotherapy, the chemotherapy is warmed before being used and may help the drugs get into the cancer cells better, minimize the toxicity of the drugs on normal cells, and help to kill any cancer cells left over after surgery.
    Location: Wake Forest University Health Sciences, Winston-Salem, North Carolina

  • Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

    This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.
    Location: 2 locations

  • Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).

    This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC chemotherapy versus SoC chemotherapy alone as first line treatment in patients with metastatic non small-cell lung cancer (NSCLC) with tumors that lack activating epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) fusions.
    Location: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

  • Nivolumab with or without Ipilimumab or Chemotherapy in Treating Patients with Previously Untreated Stage I-IIIA Non-small Cell Lung Cancer

    This phase II trial studies how well nivolumab works when given alone and in combination with ipilimumab or chemotherapy in treating patients with previously untreated stage I-IIIA non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as cisplatin, docetaxel, and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab with ipilimumab or chemotherapy may work better in treating patients with non-small cell lung cancer compared to chemotherapy alone.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Study of Pembrolizumab in Locally Advanced Esophageal Adenocarcinoma

    This is a randomized, multicenter phase II study of pembrolizumab in combination with chemotherapy and chemoradiation in locally advanced esophageal adenocarcinoma to examine the safety and efficacy of the combination of pembrolizumab with chemotherapy and chemoradiation in locally advanced esophageal adenocarcinoma as assessed by 1 year disease free survival rate.
    Location: USC / Norris Comprehensive Cancer Center, Los Angeles, California

  • High Doses of Vitamin C with Chemotherapy and Radiation Therapy in Treating Patients with Non-Small Cell Lung Cancer

    This phase II trial studies how well high doses of ascorbic acid (vitamin C) work in combination with chemotherapy and radiation therapy in patients with non-small cell lung cancer. High doses of intravenous vitamin C may change chemoradiation treatment effectiveness and / or tolerability. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fractionated radiation therapy uses smaller doses of radiation therapy over time and may kill more tumor cells and have fewer side effects. Using high doses of vitamin C with chemotherapy and radiation therapy may work better in treating patients with non-small cell lung cancer.
    Location: University of Iowa / Holden Comprehensive Cancer Center, Iowa City, Iowa

  • Palbociclib with Cisplatin or Carboplatin in Treating Patients with Advanced Solid Tumors

    This phase I trial studies the side effects and best dose of palbociclib with cisplatin or carboplatin in treating patients with solid tumors that have spread to other places and usually cannot be cured or controlled with treatment. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving palbociclib with cisplatin or carboplatin may help stop tumor growth in patients with advanced solid tumors.
    Location: Emory University Hospital / Winship Cancer Institute, Atlanta, Georgia

  • Pembrolizumab, Paclitaxel, and Carboplatin for the Treatment of Stage III-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

    This phase II trial studies how well pembrolizumab, paclitaxel, and carboplatin work in treating patients with stage III-IV ovarian, primary peritoneal, or fallopian tube cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab, paclitaxel, and carboplatin may work better in treating patients with ovarian, primary peritoneal, or fallopian tube cancer compared to paclitaxel and carboplatin without pembrolizumab.
    Location: University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

  • High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients with High-Risk Neuroblastoma

    This phase II trial studies how well high-dose, or myeloablative, chemotherapy and stem cell transplant works in treating patients with neuroblastoma that is at high risk of spreading. Myeloablative chemotherapy uses high doses of chemotherapy to kill cells in the bone marrow, both cancer cells and healthy cells. Healthy stem cells from the patient that were collected before chemotherapy are then returned to the patient in a stem cell transplant to replace the cells that were killed by chemotherapy. Myeloablative chemotherapy and stem cell transplant may be an effective treatment for patients with high-risk neuroblastoma.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

  • Docetaxel and Carboplatin in Treating Patients with Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1 / 2 Pathway

    This pilot phase II trial studies docetaxel and carboplatin in treating patients with castration resistant prostate cancer that has spread from the primary site (place where it started) to other places in the body (metastatic) and contains inactivated genes in the BRCA 1 / 2 pathway. Drugs used in chemotherapy, such as docetaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington

  • Women’s MoonShot: Neoadjuvant Treatment with PaCT for Patients with Locally Advanced TNBC

    This phase II trial studies how well panitumumab, carboplatin and paclitaxel work in treating patients with newly diagnosed triple negative breast cancer that is limited to the breast and possibly to the nearby lymph nodes (locally advanced). This treatment study is linked to NCI-2015-00191 protocol, which uses a baseline biopsy to determine the neoadjuvant therapy that matches the sub-type of triple negative breast cancer (TNBC). Immunotherapy with panitumumab, may induce changes in body’s immune system and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving panitumumab, carboplatin and paclitaxel before surgery may be an effective treatment for breast cancer by making the tumor smaller and reducing the amount of normal tissue that needs to be removed.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Carboplatin and Paclitaxel with Pertuzumab and Trastuzumab or Bevacizumab in Treating Patients with Breast Cancer

    This phase II trial studies the side effects and how well carboplatin and paclitaxel given in combination with pertuzumab and trastuzumab or bevacizumab work in treating patients with breast cancer. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as pertuzumab and bevacizumab, may interfere with the ability of tumor cells to grow and spread. Trastuzumab is a form of targeted therapy because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body's immune system. Giving carboplatin and paclitaxel together with pertuzumab and trastuzumab or bevacizumab may kill more tumor cells.
    Location: UC Irvine Health / Chao Family Comprehensive Cancer Center, Orange, California

  • Combination Chemotherapy and Radiation Therapy in Treating Patients with Newly Diagnosed Stage I-II Nasal NK Cell Lymphoma

    This phase II trial studies the side effects and how well combination chemotherapy and radiation therapy work in treating patients with newly diagnosed state I-II nasal natural killer (NK) cell lymphoma. Drugs used in chemotherapy, such as dexamethasone, etoposide, ifosfamide, and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill cancer cells and shrink tumors. Giving more than one drug (combination chemotherapy) with radiation therapy may kill more cancer cells.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Combination Chemotherapy in Treating Patients with Newly Diagnosed, Previously Untreated Intraocular Retinoblastoma

    This clinical trial studies combination chemotherapy in treating patients with newly diagnosed, previously untreated intraocular retinoblastoma. Drugs used in chemotherapy, such as vincristine sulfate, carboplatin, topotecan hydrochloride, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. In this trial, the first two cycles of chemotherapy will be given directly to the eye, and followed by additional chemotherapy. Giving the first two cycles of chemotherapy directly into the eye may improve the tumor's response to treatment.
    Location: Saint Jude Children's Research Hospital, Memphis, Tennessee

  • Docetaxel, Cisplatin and Fluorouracil in Treating Patients with Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer

    This phase II trial studies how well docetaxel, cisplatin and fluorouracil work in treating patients with previously untreated stage II-IV nasal cavity and / or paranasal sinus cancer. Drugs used in chemotherapy, such as docetaxel, cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients with Newly Diagnosed Primary Central Nervous System Lymphoma

    This phase I / II trial studies the side effects of methotrexate, mannitol, rituximab, and carboplatin and to see how well they work in treating patients with primary central nervous system lymphoma. Drugs used in chemotherapy, such as methotrexate and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Osmotic blood-brain barrier disruption uses mannitol to open the blood vessels around the brain and allow cancer-killing substances to be carried directly to the brain. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Giving methotrexate, mannitol, rituximab, and carboplatin together may be an effective treatment for primary central nervous system lymphoma.
    Location: OHSU Knight Cancer Institute, Portland, Oregon

  • Combination Chemotherapy with or without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients with Malignant Brain Tumors

    This randomized phase II trial studies how well giving combination chemotherapy with or without sodium thiosulfate works in preventing low platelet count while treating patients with malignant brain tumors. Drugs used in chemotherapy, such as carboplatin, cyclophosphamide, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Sodium thiosulfate may prevent low platelet counts in patients receiving chemotherapy. It is not yet known whether combination chemotherapy is more effective with or without sodium thiosulfate in preventing low platelet count during treatment for brain tumors.
    Location: OHSU Knight Cancer Institute, Portland, Oregon

  • Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)

    The purpose of this study is to compare pembrolizumab + adjuvant chemotherapy with placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to disease-free survival (DFS) as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to overall survival (OS). The primary hypotheses are that pembrolizumab + adjuvant chemotherapy is superior to placebo + adjuvant chemotherapy, with or without radiotherapy, with respect to DFS as assessed radiographically by the investigator or by histopathologic confirmation of suspected disease recurrence, and with respect to OS.
    Location: 4 locations

  • A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin / Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin / Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

    The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin / cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin / cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase:- Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B).
    Location: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California