Clinical Trials Using Dexamethasone

Clinical trials are research studies that involve people. The clinical trials on this list are studying Dexamethasone. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 126-147 of 147
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  • A Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma

    This study is designed to evaluate the safety and preliminary efficacy of venetoclax combined with pomalidomide and dexamethasone in participants with relapsed or refractory (R / R) multiple myeloma (MM) who have received at least 1 prior line of therapy. The study will consist of 2 parts: Part 1 (dose escalation) and Part 2 (dose expansion). For Part 2 the participants will be divided into 2 cohorts, participants positive for t(11;14) translocation and participants negative for t(11;14) translocation.
    Location: 5 locations

  • A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy

    This is a Phase 3, multicenter, randomized, double blind, placebo-controlled study evaluating the efficacy and safety of venetoclax plus bortezomib and dexamethasone in subjects with relapsed or refractory multiple myeloma who are considered sensitive or naïve to proteasome inhibitors and received 1 to 3 prior lines of therapy for multiple myeloma.
    Location: Duke University Medical Center, Durham, North Carolina

  • Palbociclib and Dexamethasone in Treating Patients with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

    This phase I trial studies the side effects and best dose of palbociclib when given together with dexamethasone in treating patients with B-cell acute lymphoblastic leukemia that has come back after a period of improvement or does not respond to treatment. Palbociclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Dexamethasone is a steroid medication that is used in combination with other medications to treat B-cell acute lymphoblastic leukemia. Giving palbociclib together with dexamethasone may work better in treating patients with B-cell acute lymphoblastic leukemia.
    Location: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

  • Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients with Relapsed Multiple Myeloma

    This phase I / II trial studies the side effects and best dose of venetoclax when given together with ixazomib citrate and dexamethasone and to see how well they work in treating patients with multiple myeloma that has come back. Venetoclax and ixazomib citrate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax together with ixazomib citrate and dexamethasone may work better in treating patients with multiple myeloma.
    Location: 7 locations

  • Ibrutinib, Lenalidomide, and Dexamethasone in Treating Patients with Multiple Myeloma Ineligible for Transplant

    This phase I / II trial studies the best dose and side effects of ibrutinib when given together with lenalidomide and dexamethasone and how well they work in treating patients with multiple myeloma that are not eligible for transplant. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ibrutinib, lenalidomide, and dexamethasone may work better in treating patients with multiple myeloma.
    Location: Mayo Clinic in Florida, Jacksonville, Florida

  • Selinexor, High-Dose Melphalan, and Dexamethasone before Stem Cell Transplant in Treating Patients with Multiple Myeloma

    This phase I / II trial studies the side effects and best dose of selinexor and how well it works when given together with high-dose melphalan and dexamethasone before stem cell transplant in treating patients with multiple myeloma. Selinexor may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving chemotherapy, such as melphalan and dexamethasone, before a stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient’s bone marrow for new blood-forming cells (stem cells) to grow. After treatment, stem cells are collected from the patient's blood and stored. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Giving selinexor, high-dose melphalan, and dexamethasone before stem cell transplant may work better in treating patients with multiple myeloma.
    Location: Moffitt Cancer Center, Tampa, Florida

  • R-(-)-Gossypol Acetic Acid with Lenalidomide and Dexamethasone in Treating Patients with Relapsed Symptomatic Multiple Myeloma

    This phase I / II trial studies the side effects and best dose of R-(-)-gossypol acetic acid when given together with lenalidomide and dexamethasone and to see how well it works in treating patients with multiple myeloma, also known as plasma cell myeloma, that has come back after a period of improvement or has gotten worse after treatment. R-(-)-gossypol acetic acid may stop the growth of cancer cells by recognizing certain proteins and stimulating programmed cell death. Lenalidomide may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving R-(-)-gossypol acetic acid with lenalidomide and dexamethasone may work better in treating patients with multiple myeloma.
    Location: Mayo Clinic in Florida, Jacksonville, Florida

  • HDAC Inhibitor AR-42 and Pomalidomide in Treating Patients with Relapsed Multiple Myeloma

    This phase Ib trial studies the side effects and best dose of histone deacetylase (HDAC) inhibitor AR-42 (AR-42) when given together with pomalidomide in treating patients with multiple myeloma that has returned after a period of improvement. HDAC inhibitor AR-42 may work to stop cancer growth by blocking an enzyme needed for cell growth. Pomalidomide is a drug used in chemotherapy that works to stop the growth of cancer cells by causing them to die. Giving HDAC inhibitor AR-42 together with pomalidomide may cause patients to respond better to treatment.
    Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

  • Isatuximab and Carfilzomib with or without Dexamethasone and Lenalidomide in Treating Patients with Relapsed or Refractory Multiple Myeloma

    This phase Ib trial studies the side effects and best dose of isatuximab when given together with carfilzomib with or without dexamethasone and lenalidomide in treating patients with multiple myeloma that has returned after a period of improvement (relapsed) or has not respond to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as isatuximab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone and lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving isatuximab and carfilzomib with or without dexamethasone and lenalidomide may be a better treatment for patients with multiple myeloma.
    Location: 3 locations

  • Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients with Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma

    This partially randomized phase II trial studies how well brentuximab vedotin or crizotinib and combination chemotherapy works in treating patients with newly diagnosed stage II-IV anaplastic large cell lymphoma. Brentuximab vedotin is a monoclonal antibody, called brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to CD30 positive cancer cells in targeted way and delivers vedotin to kill them. Crizotinib and methotrexate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether brentuximab vedotin and combination chemotherapy is more effective than crizotinib and combination chemotherapy in treating anaplastic large cell lymphoma.
    Location: 144 locations

  • Ixazomib Citrate, Cyclophosphamide, and Dexamethasone in Treating Patients with Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis

    This phase I / II trial studies the side effects and the best dose of cyclophosphamide when given together with ixazomib citrate and dexamethasone in treating patients with previously untreated symptomatic multiple myeloma or light chain amyloidosis. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Anti-inflammatory drugs, such as dexamethasone lower the body’s immune response and are used with other drugs in the treatment of some types of cancer. Ixazomib citrate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving cyclophosphamide together with ixazomib citrate and dexamethasone may be a better treatment for multiple myeloma or light chain amyloidosis.
    Location: Mayo Clinic, Rochester, Minnesota

  • Olanzapine with or without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

    This phase III trial studies how well olanzapine with or without fosaprepitant dimeglumine works in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting. Olanzapine and fosaprepitant dimeglumine may help control nausea and vomiting in patients during chemotherapy. Olanzapine is usually given in combination with other drugs, including fosaprepitant dimeglumine. It is not yet known if olanzapine, when given with other drugs, is still effective without using fosaprepitant dimeglumine for controlling nausea and vomiting.
    Location: 456 locations

  • Testing the Use of Dexamethasone Mouthwash to Prevent or Treat Painful Mouth Sores in Patients being Treated with Everolimus

    This phase III trial studies how well dexamethasone works in reducing everolimus-induced oral stomatitis in patients with cancer. Dexamethasone may help to reduce the everolimus-induced oral stomatitis so as to improve quality of life in cancer patients.
    Location: 311 locations

  • Netupitant / Palonosetron Hydrochloride and Dexamethasone with or without Prochlorperazine or Olanzapine in Improving Chemotherapy-Induced Nausea and Vomiting in Patients with Breast Cancer

    This randomized phase III trial studies how well netupitant / palonosetron hydrochloride and dexamethasone with or without prochlorperazine or olanzapine work in improving chemotherapy-induced nausea and vomiting in patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
    Location: 312 locations

  • Dexamethasone in Controlling Dyspnea in Patients with Cancer

    This phase III trial studies how well dexamethasone works in controlling dyspnea in patients with cancer. Dexamethasone may help control dyspnea (shortness of breath) and improve lung function and quality of life in cancer patients.
    Location: 3 locations

  • Study of Nerve Block Pain Management in Patients Undergoing a Double Mastectomy with Immediate Reconstruction

    This phase IV trial compares the effects of different injection sites for standard nerve blocks given before double mastectomy with immediate reconstruction. Nerve blocks help with pain relief during surgery and recovery, and they can be given in different areas of the body, including the upper back and / or upper chest area. While nerve blocks are standard of care for this type of surgery, it is not known which nerve block approach helps relieve pain after surgery the most. This trial studies whether one site or a combination of sites is better than the others at decreasing pain during surgery and reducing the need for pain medication after surgery.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York

  • Physical Activity with or without Dexamethasone in Reducing Cancer-Related Fatigue in Patients with Locally Advanced, Metastatic, or Recurrent Cancer

    This phase II / III trial studies how well physical activity with or without dexamethasone works in reducing cancer-related fatigue in patients with cancer that has spread to other places in the body or has come back. Dexamethasone may decrease the body’s immune response. Combining physical activity with dexamethasone may help to treat fatigue in patients with cancer.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Caudal Nerve Block in Reducing Post-Operative Pain in Adult Patients Undergoing Penile Prosthesis Surgery

    This randomized phase III trial studies caudal nerve block to see how well it works compared with general anesthesia in reducing post-operative pain in adult patients undergoing penile prosthesis surgery. A caudal nerve block is a local anesthetic injected near the tailbone which may help reduce the level of pain and length of hospital stay after surgery.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Rolapitant Hydrochloride in Preventing Nausea / Vomiting in Patients with Sarcoma Receiving Chemotherapy

    This randomized phase II trial studies how well rolapitant hydrochloride works in preventing nausea / vomiting in patients with sarcoma receiving chemotherapy. Antiemetic drugs, such as rolapitant hydrochloride, may help control or prevent nausea and vomiting in patients treated with chemotherapy.
    Location: M D Anderson Cancer Center, Houston, Texas

  • Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)

    The purpose of this study is to evaluate the safety and tolerability of a 3-day intravenous (IV) fosaprepitant (MK-0517) regimen for the prevention of CINV in pediatric participants scheduled to receive emetogenic chemotherapy.
    Location: 2 locations

  • Whole Body-MRI or PET Scan and Image-Guided Biopsy in Assessing Response in Participants with Multiple Myeloma Receiving Carfilzomib, Lenalidomide, and Dexamethasone

    This phase II trial studies how well whole body-magnetic resonance imaging (WB-MRI) or positron emission tomography (PET) and image-guided biopsy work in assessing response in participants with multiple myeloma receiving carfilzomib, lenalidomide, and dexamethasone. Diagnostic procedures, such as MRI and PET, may help measure a participant's response to treatment. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. WB-MRI or PET and image-guided biopsy may improve response assessment strategy after chemotherapy in participants with multiple myeloma.
    Location: Yale University, New Haven, Connecticut

  • Dexamethasone Effects in Patients with Newly Diagnosed, Recurrent, or Progressive Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography

    This pilot phase II trial studies the effects of dexamethasone in patients with non-small cell lung cancer that is newly diagnosed, has come back, or is growing, spreading, or getting worse. Drugs such as dexamethasone can affect how tumors grow and respond to treatments. Imaging tests, such as fluoro-L-thymidine (FLT) positron emission tomography, use a small amount of radioactive substance to show changes in tumor cells. Studying the effects of dexamethasone on lung tumors using FLT positron emission tomography may help doctors plan better treatments.
    Location: Wayne State University / Karmanos Cancer Institute, Detroit, Michigan


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