anti-FOLR1 CoStAR-expressing autologous tumor-infiltrating lymphocytes ITIL-306
A preparation of autologous tumor infiltrating lymphocytes (TILs) genetically engineered to express a co-stimulatory antigen receptor (CoStAR) specific for folate receptor alpha (FolRa; FOLR1) and linked to the co-stimulatory domains CD28 and CD40, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306 specifically target, bind to and kill the FOLR1-expressing tumor cells. In addition, ITIL-306, by binding to FOLR1, is able to activate the TILs through the costimulatory signals. This increases T-cell proliferation and activation in the tumor microenvironment (TME), thereby enhancing the T-cell-mediated anti-tumor immune response against the FOLR1-expressing tumor cells. FOLR1 is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues. CoStAR provides synthetic costimulation in the TME and increases T-cell proliferation and survival, and improves the effector function of T cells, which may boost the efficacy of TILs.
Synonym: | anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306 autologous anti-FOLR1 CoStAR-TILs ITIL-306 autologous CoStAR-TILs ITIL-306 CoStAR-modified autologous TILs ITIL-306 |
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Code name: | ITIL 306 ITIL-306 ITIL306 |