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Adult Non-Hodgkin Lymphoma Treatment (PDQ®)

Patient Version
Last Modified: 02/06/2013

Treatment Options for Non-Hodgkin Lymphoma

Indolent, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma
Aggressive, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma
Indolent, Noncontiguous Stage II/III/IV Adult Non-Hodgkin Lymphoma
Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin Lymphoma
Adult Lymphoblastic Lymphoma
Diffuse Small Noncleaved Cell/Burkitt Lymphoma
Waldenström Macroglobulinemia
Recurrent Adult Non-Hodgkin Lymphoma
        Indolent, Recurrent Adult Non-Hodgkin Lymphoma
        Aggressive, Recurrent Adult Non-Hodgkin Lymphoma
Non-Hodgkin Lymphoma During Pregnancy
        Aggressive Non-Hodgkin Lymphoma During the First Trimester of Pregnancy
        Aggressive Non-Hodgkin Lymphoma During the Second and Third Trimesters of Pregnancy
        Indolent Non-Hodgkin Lymphoma During Pregnancy

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Indolent, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma

Treatment of indolent, stage I and contiguous stage II adult non-Hodgkin lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with indolent, stage I adult non-Hodgkin lymphoma and indolent, contiguous stage II adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Aggressive, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma

Treatment of aggressive, stage I and contiguous stage II adult non-Hodgkin lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with aggressive, stage I adult non-Hodgkin lymphoma and aggressive, contiguous stage II adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Indolent, Noncontiguous Stage II/III/IV Adult Non-Hodgkin Lymphoma

Treatment of indolent, noncontiguous stage II /III /IV adult non-Hodgkin lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with indolent, noncontiguous stage II adult non-Hodgkin lymphoma, indolent, stage III adult non-Hodgkin lymphoma and indolent, stage IV adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin Lymphoma

Treatment of aggressive, noncontiguous stage II /III /IV adult non-Hodgkin lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with aggressive, noncontiguous stage II adult non-Hodgkin lymphoma, aggressive, stage III adult non-Hodgkin lymphoma and aggressive, stage IV adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Adult Lymphoblastic Lymphoma

Treatment of adult lymphoblastic lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with adult lymphoblastic lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Diffuse Small Noncleaved Cell/Burkitt Lymphoma

Treatment of adult diffuse small noncleaved cell/Burkitt lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with adult Burkitt lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Waldenström Macroglobulinemia

Treatment of Waldenström macroglobulinemia may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with Waldenström macroglobulinemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Recurrent Adult Non-Hodgkin Lymphoma

Indolent, Recurrent Adult Non-Hodgkin Lymphoma

Treatment of indolent, recurrent adult non-Hodgkin lymphoma may include the following:

Treatment of indolent lymphoma that comes back as aggressive lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with indolent, recurrent adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Aggressive, Recurrent Adult Non-Hodgkin Lymphoma

Treatment of aggressive, recurrent adult non-Hodgkin lymphoma may include the following:

Treatment of aggressive lymphoma that comes back as indolent lymphoma may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with aggressive, recurrent adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Non-Hodgkin Lymphoma During Pregnancy

Aggressive Non-Hodgkin Lymphoma During the First Trimester of Pregnancy

When aggressive non-Hodgkin lymphoma is diagnosed in the first trimester of pregnancy, medical oncologists may advise the patient to end her pregnancy so that treatment may begin. Treatment is usually chemotherapy with or without radiation therapy.

Aggressive Non-Hodgkin Lymphoma During the Second and Third Trimesters of Pregnancy

When possible, treatment should delayed until after an early delivery, so that the anticancer drugs or radiation therapy will not affect the fetus. However, sometimes the cancer will need to be treated right away to increase the mother's chance of survival.

Indolent Non-Hodgkin Lymphoma During Pregnancy

Women who have indolent (slow-growing) non-Hodgkin lymphoma can usually delay treatment with watchful waiting.