Screening Clinical Trials for Breast Neoplasm

Clinical trials are research studies that involve people. The clinical trials on this list are for breast neoplasm screening. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-20 of 20
  • Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

    This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment.
    Location: 109 locations

  • Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

    Most physicians still use a one-size-fits-all approach to breast screening in which all women, regardless of their personal history, family history or genetics (except BRCA carriers) are recommended to have annual mammograms starting at age 40. Mammograms benefit women by detecting cancers early when they are easier to treat, but they are not perfect. Recent news stories have discussed some of the potential harms: large numbers of positive results that cause stressful recalls for additional mammograms and biopsies. With the current screening approach, half of the women who undergo annual screening for ten years will have at least one false positive biopsy. Potentially more important are cancer diagnoses for growths that might never come to clinical attention if left alone (called "overdiagnosis"). This can lead to unnecessary treatment. Even more concerning is evidence that up to 20% of breast cancers detected today may fall into the category of "overdiagnosis." This study compares annual screening with a risk-based breast cancer screening schedule, based upon each woman's personal risk of breast cancer. The investigators have designed the study to be inclusive of all, so that even women who might be nervous about being randomly assigned to receive a particular type of care (a procedure that is typical in clinical studies) will still be able to participate by choosing the type of care they receive. For participants in the risk-based screening arm, each woman will receive a personal risk assessment that includes her family and medical history, breast density measurement and tests for genes (mutations and variations) linked to the development of breast cancer. Women who have the highest personal risk of developing breast cancer will receive more frequent screening, while women with a lower personal risk would receive less frequent screening. No woman will be screened less than is recommended by the USPSTF breast cancer screening guidelines. If this study is successful, women will gain a realistic understanding of their personal risk of breast cancer as well as strategies to reduce their risk, and fewer women will suffer from the anxiety of false positive mammograms and unnecessary biopsies. The investigators believe this study has the potential to transform breast cancer screening in America.
    Location: 10 locations

  • Combined Breast MRI and Biomarker Strategies in Identifying High-risk Breast Cancer Patients

    This clinical trial studies normal breast tissue changes combined with breast magnetic resonance imaging (MRI) that may suggest the beginnings of cancer development. Using breast tissue markers in combination with breast imaging such as MRI may help to more accurately assess a woman's risk of developing breast cancer.
    Location: 5 locations

  • Patient Activation with or without Primary Care Provider Activation in Promoting Breast Cancer Screening in Childhood Cancer Survivors Previously Treated with Chest Radiation Therapy

    This phase III trial studies patient and primary care provider activation to see how well it works compared with patient activation alone in promoting breast cancer screening in childhood cancer survivors previously treated with chest radiation therapy. Patient and primary care provider activation may encourage screening and early detection of breast cancer, with the potential to improve the health and quality of life of female childhood cancer survivors.
    Location: 3 locations

  • Collection of Biological Specimens with or without Fine Needle Aspiration in Predicting Short Term Risk in Patients with High Risk for Breast Cancer

    This randomized clinical trial studies the collection of biological specimens with or without fine needle aspiration in predicting short term risk in patients with high risk for breast cancer. Studying samples of tissue collected using a procedure called fine needle aspiration, where a a few cells and breast fluid are removed from two different areas of the breast, with or without collection of blood, saliva, urine, and / or stool, may help doctors predict the likelihood of developing breast cancer over a five year period.
    Location: 2 locations

  • Screening MRI Scan for the Imaging of Metastatic, Unresectable, or Recurrent Breast Cancer

    This trial studies the usefulness of a screening MRI scan of the brain in patients with breast cancer that has spread to other places in the body (metastatic), cannot be removed by surgery (unresectable), or has come back (recurrent). Screening MRIs of the brain may be helpful in assessing for brain involvement by breast cancer, if it has occurred.
    Location: 2 locations

  • Online Genetics Educational Video with or without Pre- and / or Post-Telephone Genetics Counseling in Assessing Cancer-Risk Distress in Patients with Triple Negative Breast Cancer

    This randomized clinical trial studies how well online genetics educational video with or without pre- and / or post-telephone genetics counseling works in assessing cancer-risk distress in patients with triple negative breast cancer. Online genetic education and telephone genetic counseling may help the doctors learn the stress a person feels about their risk of cancer.
    Location: 2 locations

  • Safety and Performance of the Multi-Modal UltraSound Tomography (MUST) Device in Breast Cancer Screening

    This is a single-center, pilot study being conducted to evaluate the safety and performance of the investigational device (MUST) in detecting malignant lesions in breast tissue.
    Location: Beth Israel Deaconess Medical Center, Boston, Massachusetts

  • LymphaTech Scanner for Breast Cancer-Related Lymphedema Screening

    This trial investigates how well the LymphaTech scanner works for early detection of breast cancer-related lymphedema compared to perometry. Breast cancer-related lymphedema is characterized by an abnormal build up of protein-rich fluid in the interstitial tissues due to improper drainage within the lymphatic system. This build up may cause swelling of the arm, trunk, breast, and / or shoulder in the side treated for breast cancer. LymphaTech scanner may help doctors find breast cancer-related lymphedema sooner, when it may be easier to treat.
    Location: Massachusetts General Hospital Cancer Center, Boston, Massachusetts

  • A Multi-Modality Surveillance Program in Screening Women at High Risk for Breast Cancer

    The purpose of the Personalized Risk-based Imaging Surveillance Model (PRISM) study is to develop a personalized approach to screening women at high risk for breast cancer in diverse populations. A multi-modality surveillance program includes cognitive-behavioral self-management of anxiety therapy, clinical hypnosis, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), and mammogram. This study will also evaluate quality of life and measures of psychological well-being during breast cancer screening and compare breast MRI and mammogram in a high-risk population. Additionally, it will evaluate whether a new intervention for anxiety-reduction will help to improve adherence in high risk women undergoing intensive surveillance. Women participating in this study will learn self-management of anxiety using a technique called clinical hypnosis, which may help participants feel more relaxed during MRI. DCE MRI and mammogram may help doctors to detect breast cancer earlier when it is easier to treat.
    Location: University of Chicago Comprehensive Cancer Center, Chicago, Illinois

  • Restriction Spectrum Imaging or Conventional and Abbreviated MRI in Screening Participants Who May Have Breast Cancer

    This trial compares restriction spectrum imaging (RSI) with conventional and abbreviated magnetic resonance imaging (MRI) in screening participants who may have breast cancer. MRI uses a strong magnet to produce detailed pictures of the inside of the body and RSI is a technique that aims to improve the pictures produced during a MRI exam. RSI may be a better way to screen for breast cancer.
    Location: Beth Israel Deaconess Medical Center, Boston, Massachusetts

  • Contrast Enhanced Spectral Mammography and Magnetic Resonance Imaging in Detecting Breast Cancer

    This trial studies how well contrast enhanced spectral mammography and magnetic resonance imaging work in detecting breast cancer. Diagnostic procedures, such as contrast enhanced spectral mammography and magnetic resonance imaging, may help find and diagnose breast cancer. Comparing results of diagnostic procedures done before biopsy may help doctors predict a patient's response to treatment and help plan the best treatment.
    Location: Beth Israel Deaconess Medical Center, Boston, Massachusetts

  • Disseminated Tumor Cells in Blood and Bone Marrow Samples from Patients Previously Treated for Breast Cancer

    This trial studies disseminated tumor cells in blood and bone marrow samples from patients previously treated for breast cancer. Studying samples of blood and bone marrow from patients with breast cancer in the laboratory may help doctors to determine whether there are any dormant tumor cells in the body. It may also help doctors to better understand what disseminated tumor cells are and how they can be best treated to improve the treatment and prevention of breast cancer in the future.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • Whole Breast Ultrasound and Digital Tomosynthesis Mammography in Screening Women with Denser Breasts for Breast Cancer

    This clinical trial studies how well digital tomosynthesis mammography combined with whole breast ultrasound works in screening for breast cancer in women with denser breast tissue. Digital tomosynthesis mammography combined with whole breast ultrasound may improve early breast cancer detection in women with denser breasts and allow physicians to plan better treatment for breast cancer.
    Location: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

  • Fluid Measurements and MRI in Determining Biomarkers of Lymphatic Dysfunction in Patients with Breast Cancer

    This trial uses fluid measurements of the arm and MRI to determine biomarkers of lymphatic dysfunction in patients with breast cancer. Studying the lymphatic system (the part of your body that helps to process and clear waste products) in different ways will help doctors understand more about lymphedema (excess fluid after lymph nodes are removed) and help with prevention and management of lymphedema in patients with breast cancer.
    Location: Vanderbilt University / Ingram Cancer Center, Nashville, Tennessee

  • Contrast Enhanced Spectral Mammography in Predicting Breast Cancer in Participants with Atypical Ductal Hyperplasia

    This pilot trial studies how well contrast enhanced spectral mammography works in predicting breast cancer in participants with atypical ductal hyperplasia. Contrast enhanced mammography is a type of mammogram that uses contrast material (dye or other substance) combined with the mammogram to highlight areas that might be breast cancer and that could be missed on the mammogram alone. Diagnostic procedures, such as contrast enhanced spectral mammography, may help prevent unnecessary surgery in many participants with the diagnosis of atypical ductal hyperplasia.
    Location: Beth Israel Deaconess Medical Center, Boston, Massachusetts

  • Quantitative Cardiac Magnetic Resonance Imaging in Finding Heart Complications in Patients with Breast Cancer Receiving Chemotherapy

    This research trial studies quantitative cardiac magnetic resonance imaging in finding heart complications in patients with breast cancer receiving chemotherapy. One of the side effects in patients receiving chemotherapy is heart complications in which the heart muscle is weakened and no longer able to pump sufficient amounts of blood throughout the body, which can lead to shortness of breath, swollen ankles and feet, lack of energy, and a reduced capacity to carry out day-to-day activities. Identifying early signs of such heart complications using cardiac magnetic resonance may allow preventative treatment options to be made available in future.
    Location: Beth Israel Deaconess Medical Center, Boston, Massachusetts

  • Circadian Thermal Sensing to Detect Breast Disease

    The purpose of this study is to determine if Cyrcadia's Circadian Biometric Recorder (CBR™), which is attached to soft biometric patches worn on the body, can improve early breast cancer detection along with mammography or as a stand alone device.
    Location: See Clinical Trials.gov

  • Evaluation of Perforator Phase Contrast Angiography in Developing Surgery Plans for Patients with Breast Cancer Undergoing Breast Reconstruction with Free-Flap Methods After Mastectomy

    This phase II trial studies how well an imaging technique called perforator phase contrast angiography (pPCA) works in developing surgery plans for patients with breast cancer undergoing breast reconstruction after breast removal (mastectomy) using abdominal-based free flap methods. Free flaps are units of tissue transferred from one area of the body to another with an intact blood supply. pPCA uses magnetic resonance imaging (MRI) to create images of blood vessels inside the body. Using pPCA may help doctors develop better surgical plans for patients with breast cancer undergoing post-mastectomy reconstruction surgery with free flap methods.
    Location: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

  • Non-Contrast DWI for Breast Cancer Screening in Women with Dense Breasts

    This study investigates how well diffusion-weighted imaging (DWI) works in identifying breast cancer in women with dense breasts. DWI is a short non-contrast MRI technique that may detect and characterize breast cancer in women with dense breasts. Adding DWI MRI to conventional mammography may help to improve the early detection of breast cancer not visible on standard mammography. This MRI may identify additional areas in either breast that represent a breast cancer (true positives). The purpose of this study is to see if new MRI imaging techniques can lead to earlier detection of breast cancer in women with dense breasts.
    Location: Fred Hutch / University of Washington Cancer Consortium, Seattle, Washington