Technetium Tc-99m Sestamibi Molecular Breast Imaging in Predicting Tumor Response in Patients with Locoregional Invasive Breast Cancer Receiving Neoadjuvant Chemotherapy
- Any race
- Has biopsy-proven invasive breast cancer (Breast Imaging Reporting and Data System [BI-RADS] 6) and scheduled for neoadjuvant chemotherapy (NAC)
- Newly diagnosed biopsy proven locoregional invasive breast cancer at MD Anderson Cancer Center, or referred to MD Anderson for treatment after initial radiologic (mammographic, sonographic, etc.) exams at an outside institution in whom NAC is planned
- Patients with stage T1 or greater (T1-T4), nodal involvement (N0-N3), without metastasis (M0) invasive breast cancer, including patients with inflammatory breast cancer
- Patients who agree to sign an informed consent to undergo MBI
- Is pregnant (confirmed by the patient as imaging clinic standard of care) or nursing mother
- Has lesions involving chest wall
- Has known allergy to Tc 99m sestamibi
I. To evaluate the ability of technetium Tc-99m sestamibi (Tc 99m sestamibi) molecular breast imaging (MBI) to predict early response to neoadjuvant chemotherapy (NAC) and to assess residual disease at the completion of NAC in patients with locoregional invasive breast cancer.
I. To evaluate and qualitatively characterize Tc 99m sestamibi uptake by tumor on MBI at the baseline, after 2 cycles of NAC and at the completion of NAC.
II. To compare assessment of tumor response to NAC by MBI with digital mammography (DM), and breast ultrasound (US) exams.
III. To compare tumor size and distribution observed from MBI at the completion of NAC with extent of residual disease at surgery by pathological evaluation.
IV. To develop image acquisition and processing algorithm that quantifies the Tc 99m tumor uptake.
Patients undergo technetium Tc-99m sestamibi molecular breast imaging over 45 minutes at baseline (before start of NAC), after 2 courses of NAC (6-12 weeks, depending on the regimen), and the completion of NAC but before surgery. Patients also undergo breast ultrasound and mammographic imaging as standard of care at the same time points.
Trial Phase Phase NA
Trial Type Diagnostic
M D Anderson Cancer Center
Gaiane M. Rauch
- Primary ID 2014-0812
- Secondary IDs NCI-2015-00035
- Clinicaltrials.gov ID NCT02324387