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Study of BMS-986158 in Subjects With Select Advanced Cancers

Trial Status: Active

The purpose of this study is to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of BMS-986158 in subjects with select advanced cancers

Inclusion Criteria

  • Must have select advanced cancers with specific genetic profiles
  • Must have received appropriate standard of care
  • At least one measurable lesion at baseline
  • Expected to have life expectancy of at least 3 months
  • Eastern Cooperative Oncology Group (ECOG) of 0 to 1

Exclusion Criteria

  • Concomitant second malignancies
  • Uncontrolled or significant cardiovascular disease
  • Inadequate bone marrow function
  • Chronic gastrointestinal illness
  • Prior treatment with Bromodomain and Extra-Terminal (BET) inhibitor

California

Duarte
City of Hope Comprehensive Cancer Center
Status: ACTIVE
Contact: Mihaela C. Cristea
Phone: 626-359-8111

Colorado

Aurora
University of Colorado Hospital
Status: ACTIVE

Massachusetts

Boston
Brigham and Women's Hospital
Status: ACTIVE
Dana-Farber Cancer Institute
Status: ACTIVE

Missouri

Saint Louis
Siteman Cancer Center at Washington University
Status: IN_REVIEW

Oregon

Portland
OHSU Knight Cancer Institute
Status: ACTIVE

Trial Phase Phase I/II

Trial Type Treatment

Lead Organization
Bristol-Myers Squibb

  • Primary ID CA011-001
  • Secondary IDs NCI-2016-01458, 2015-000324-29
  • Clinicaltrials.gov ID NCT02419417

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