Tai Ji Quan, Strength Training, or Stretching for Fall Prevention and Functional Improvements in Patients with Prostate Cancer Receiving Antiandrogen Therapy

Status: Active

Description

This trial studies the use of tai ji quan, strength training, or stretching for fall prevention and improvements in physical function in patients with prostate cancer receiving antiandrogen therapy. Treatments for prostate cancer can cause side effects such as fatigue, muscle loss, and weakness which can increase the risk of falls and frailty. Group exercise training using tai ji quan, strength training, or stretching for improving balance, strength, and mobility may improve physical function, mood, and overall quality of life in patients with prostate cancer.

Eligibility Criteria

Inclusion Criteria

  • Diagnosed with histologically confirmed prostate cancer (confirmed by self-report on Health History Questionnaire. In the case a participant isn’t able to confirm this criterion, a letter will be sent to his physician.)
  • Currently on ADT for >= 6 months OR not currently receiving ADT, but received >= 6-month course within the last 10 years (confirmed by self-report on Health History Questionnaire. In the case a participant isn’t able to confirm this criterion, a letter will be sent to his physician.)
  • If they have had other treatment, such as surgery, radiation or chemotherapy, it must have been completed >= 6 weeks prior to enrollment and no concurrent adjuvant therapy other than ADT for prostate cancer (confirmed by self-report on Health History Questionnaire. In the case a participant isn’t able to confirm this criterion, a letter will be sent to his physician).
  • Meets criteria for having experienced >= 1 fall in the last year (confirmed by self-report on Health History Questionnaire) or if no falls, meets criteria for slow Timed Up and Go (TUG) time (>= 12.0 seconds) OR slow chair stand time (>= 10.0 seconds) (confirmed by baseline screening testing).

Exclusion Criteria

  • Current participation in moderate or vigorous lower-body strength training two or more times per week for 30 minutes or more or participating in tai chi two or more times per week for 30 minutes or more (confirmed by self-report on Health History Questionnaire or by discretion of the principal investigator).
  • Cognitive difficulties that preclude answering the survey questions, participating in the exercise classes or performance tests, or providing informed consent (Confirmed by the professional opinion of the principal investigator, Dr. Kerri Winters-Stone.).
  • A medical condition, movement or neurological disorder, or medication use that contraindicates participation in moderate intensity exercise (Confirmed by self-report on the Health History Questionnaire, and/or by physician clearance. If in the professional opinion of the principal investigator, Dr. Kerri Winters-Stone, contraindications other than those identified by the patient or physician are present, she may consider the participant ineligible.).
  • Not medically cleared for participation in moderate intensity exercise. (Confirmed by physician clearance.).

Locations & Contacts

Oregon

Portland
OHSU Knight Cancer Institute
Status: Active
Contact: Kerri Winters-Stone
Phone: 503-494-0183
Email: wintersk@ohsu.edu

Trial Objectives and Outline

PRIMARY OBJECTIVES:

I. To determine and compare the efficacy of tai ji quan training and strength training in reducing the incidence of falls in prostate cancer survivors on antiandrogen therapy (ADT).

SECONDARY OBJECTIVES:

I. To determine and compare the efficacy of tai ji quan training and strength training to reduce frailty and dysfunction in prostate cancer survivors on ADT.

TERTIARY OBJECTIVES:

I. To determine how well the benefits of tai ji quan and strength interventions persist over a 6-month period.

EXPLORATORY OBJECTIVES:

I. To explore the patterns and predictors of types of men (including host and treatment factors) who benefit most from tai ji quan and strength training.

OUTLINE: Patients are randomized to 1 of 3 groups.

GROUP I: Patients perform a tai ji quan routine of 8 purposeful movement forms and a set of therapeutic movements over 60 minutes 3 times a week for 6 months.

GROUP II: Patients perform multiple-joint strength training exercises over 60 minutes 3 times a week for 6 months.

GROUP III: Patients perform a series of whole body stretching exercises per American College of Sports Medicine (ACSM) guidelines over 60 minutes 3 times a week for 6 months.

After completion of study, patients are followed up at 3, 6, 9, and 12 months.

Trial Phase & Type

Trial Phase

No phase specified

Trial Type

Supportive care

Lead Organization

Lead Organization
OHSU Knight Cancer Institute

Principal Investigator
Kerri Winters-Stone

Trial IDs

Primary ID STUDY00018354
Secondary IDs NCI-2019-01422
Clinicaltrials.gov ID NCT03741335