F18 Fluciclovine PET/CT in Assessing Tumor Volume and Radiation Therapy Response in Patients with Glioblastoma Undergoing Surgery

Inclusion Criteria

• Patient is > 18 years old
• Patient is a candidate for brain tumor resection and radiation with lesion suspected to be or previously biopsy proven to be a high-grade glioma (grade 3 or 4)
• Patient is able to understand and give consent to participation in the study.

Exclusion Criteria

• Patients less than 18 years of age
• Pregnant.
• Known allergy to gadolinium-based contrast agents or F18 fluciclovine.
• Renal failure as evidenced by a glomerular filtration rate (GFR) of less than 30 mL/min/1.73 m^2.
• Pacemakers, electronic stimulation, metallic foreign bodies and devices and/or other conditions that are not MR safe, which include but are not limited to: * Electronically, magnetically, and mechanically activated implants * Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators and cardiac pacemakers * Metallic splinters in the eye * Ferromagnetic hemostatic clips in the central nervous system (CNS) or body * Cochlear implants * Other pacemakers, e.g., for the carotid sinus * Insulin pumps and nerve stimulators * Non-MR safe lead wires * Prosthetic heart valves (if dehiscence is suspected) * Non-ferromagnetic stapedial implants * Pregnancy * Claustrophobia that does not readily respond to oral medication.