Memantine for the Prevention of Cognitive Decline during Chemotherapy in Patients with Breast Cancer
- Able to provide informed consent
- Able to speak English
- Diagnosed with breast cancer, stages I-III
- Scheduled for adjuvant or neoadjuvant chemotherapy
- A history of adverse reaction to memantine
- Another cancer diagnosis with an estimated survival of less than five years
- Previous chemotherapy exposure
- Severe cognitive impairment, defined as Blessed Orientation Memory Concentration Test (BOMC) >= 11
- Pregnancy, confirmed by a negative pregnancy test within 30 days of study enrollment, or breastfeeding
- Current alcohol or drug abuse
I. To compare changes in pre- to post-chemotherapy cognitive function, as measured by Delayed Matching to Sample Test (DMS) score, in our cohort of patients with breast cancer receiving memantine hydrochloride (memantine) to historical controls.
I. To compare pre- to post-chemotherapy changes in all other objective and self-reported cognitive function measures.
II. To examine associations between objective and self-reported cognitive function with depression, anxiety, fatigue, menopausal status, baseline intelligence quotient (IQ), and perceived cognitive effort, cross-sectionally pre- and post-chemotherapy.
III. To explore the impact of cognitive decline on health-related quality of life (HRQOL), functional status, depression, and anxiety.
IV. To estimate the feasibility of conducting a clinical trial of memantine for attenuating cognitive decline in patients with breast cancer during chemotherapy.
V. To describe the safety of administering memantine to patients with breast cancer during chemotherapy.
I. To compare pre- to 6 months post-chemotherapy changes in objective and self-reported cognitive function measures.
II. To describe changes in depression, anxiety, fatigue, HRQOL, and functional status from pre- to 6 months post-chemotherapy.
OUTLINE: Beginning within 4 weeks prior to the start of chemotherapy and 1 week after chemotherapy initiation, patients receive memantine orally (PO) once daily (QD) in week 1, PO twice daily (BID) in weeks 2-4 for up to 4 weeks post-chemotherapy. At baseline and post-chemotherapy, patients also complete a cognitive assessment over 70 minutes.
Trial Phase Phase II
Trial Type Prevention
UNC Lineberger Comprehensive Cancer Center
- Primary ID LCCC1921
- Secondary IDs NCI-2020-08189
- Clinicaltrials.gov ID NCT04033419